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    Eml3 EMAP like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 102551660, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Eml3provided by RGD
    Official Full Name
    EMAP like 3provided by RGD
    Primary source
    RGD:7630023
    See related
    EnsemblRapid:ENSRNOG00000019873 AllianceGenome:RGD:7630023
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311368
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; mitotic metaphase plate congression; and regulation of mitotic spindle assembly. Predicted to be located in several cellular components, including midbody; mitotic spindle microtubule; and nucleus. Predicted to colocalize with mitotic spindle. Orthologous to human EML3 (EMAP like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 112.7), Spleen (RPKM 102.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eml3 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215255459..215266895)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205826354..205837790)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225128997..225140472)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene beta-1,3-glucuronyltransferase 3 Neighboring gene retinal outer segment membrane protein 1 Neighboring gene metastasis associated 1 family, member 2 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene uncharacterized LOC134483968

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    echinoderm microtubule-associated protein-like 3
    Names
    echinoderm microtubule associated protein like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401767.1 → NP_001388696.1  echinoderm microtubule-associated protein-like 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      215255459..215266895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231007.5 → XP_006231069.1  echinoderm microtubule-associated protein-like 3 isoform X1

      See identical proteins and their annotated locations for XP_006231069.1

      UniProtKB/TrEMBL
      A6HZX8, A6HZX9, D4A4R1
      Related
      ENSRNOP00000026938.5, ENSRNOT00000026938.8
      Conserved Domains (4) summary
      sd00039
      Location:644 → 679
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:216 → 285
      HELP; HELP motif
      cd21949
      Location:6 → 34
      TD_EMAP3; trimerization domain of echinoderm microtubule-associated protein-like 3
      cl29593
      Location:552 → 869
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006231009.5 → XP_006231071.1  echinoderm microtubule-associated protein-like 3 isoform X2

      See identical proteins and their annotated locations for XP_006231071.1

      UniProtKB/TrEMBL
      A6HZX9
      Related
      ENSRNOP00000091580.2, ENSRNOT00000114659.2
      Conserved Domains (4) summary
      COG2319
      Location:302 → 704
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:216 → 285
      HELP; HELP motif
      sd00039
      Location:592 → 627
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:500 → 817
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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