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    Mettl16 methyltransferase 16, RNA N6-adenosine [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360568, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mettl16provided by RGD
    Official Full Name
    methyltransferase 16, RNA N6-adenosineprovided by RGD
    Primary source
    RGD:1593242
    See related
    EnsemblRapid:ENSRNOG00000002764 AllianceGenome:RGD:1593242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mett10d
    Summary
    Predicted to enable RNA binding activity and RNA methyltransferase activity. Predicted to be involved in RNA metabolic process and regulation of mRNA metabolic process. Predicted to be located in cytoplasm and nucleus. Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 75.2), Adrenal (RPKM 69.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mettl16 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60139317..60185438)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (59640915..59697291)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (61626595..61682947)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene U2 spliceosomal RNA Neighboring gene MAX network transcriptional repressor Neighboring gene small G protein signaling modulator 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle. Zhang X, et al. Cell Death Dis, 2023 Sep 6. PMID 37673880, Free PMC Article
    2. Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor. Doxtader KA, et al. Mol Cell, 2018 Sep 20. PMID 30197297, Free PMC Article
    3. Human METTL16 is a N(6)-methyladenosine (m(6)A) methyltransferase that targets pre-mRNAs and various non-coding RNAs. Warda AS, et al. EMBO Rep, 2017 Nov. PMID 29051200, Free PMC Article
    4. Methylation of Structured RNA by the m(6)A Writer METTL16 Is Essential for Mouse Embryonic Development. Mendel M, et al. Mol Cell, 2018 Sep 20. PMID 30197299, Free PMC Article
    5. S-Adenosylmethionine Synthesis Is Regulated by Selective N(6)-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1. Shima H, et al. Cell Rep, 2017 Dec 19. PMID 29262316

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle.
      Title: METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U6 snRNA (adenine-(43)-N(6))-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U6 snRNA 3'-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA m(6)A methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of S-adenosylmethionine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA (adenine-N6)-methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA N6-adenosine-methyltransferase METTL16
    Names
    methyltransferase 10 domain containing
    methyltransferase 16, N6-methyladenosine
    methyltransferase like 16
    NP_001388962.1
    XP_056840651.1
    XP_056840653.1
    XP_056840655.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402033.1 → NP_001388962.1  RNA N6-adenosine-methyltransferase METTL16

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZQX2
      Related
      ENSRNOP00000003750.7, ENSRNOT00000003750.10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      60139317..60185438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_056984671.2 → XP_056840651.1  RNA N6-adenosine-methyltransferase METTL16 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQX2

    2. XM_056984673.2 → XP_056840653.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

      Related
      ENSRNOP00000097529.2, ENSRNOT00000107585.2

    3. XM_056984675.2 → XP_056840655.1  RNA N6-adenosine-methyltransferase METTL16 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.