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    Trim25 tripartite motif-containing 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 494338, updated on 2-Nov-2024

    Summary

    Official Symbol
    Trim25provided by RGD
    Official Full Name
    tripartite motif-containing 25provided by RGD
    Primary source
    RGD:1594396
    See related
    EnsemblRapid:ENSRNOG00000002341 AllianceGenome:RGD:1594396
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Efp; Znf147
    Summary
    Predicted to enable RIG-I binding activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in response to estrogen and response to vitamin D. Predicted to be located in cytoplasmic stress granule; cytosol; and nuclear body. Predicted to be active in cytoplasm. Orthologous to human TRIM25 (tripartite motif containing 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 220.2), Liver (RPKM 133.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Trim25 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (74310024..74328473)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (73812818..73831271)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (76343847..76362159)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 11 like 1 Neighboring gene coilin Neighboring gene uncharacterized LOC120095172 Neighboring gene diacylglycerol kinase epsilon Neighboring gene similar to human chromosome 17 open reading frame 67 Neighboring gene U6atac minor spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC72607

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RIG-I binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral release from host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin/ISG15 ligase TRIM25
    Names
    estrogen-responsive finger protein
    tripartite motif protein 25
    zinc finger protein 147
    NP_001009536.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009536.1NP_001009536.1  E3 ubiquitin/ISG15 ligase TRIM25

      See identical proteins and their annotated locations for NP_001009536.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061749
      UniProtKB/TrEMBL
      D4A9N5, Q6P7B3
      Related
      ENSRNOP00000052533.4, ENSRNOT00000055674.6
      Conserved Domains (4) summary
      cd00162
      Location:1356
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam10191
      Location:192314
      COG7; Golgi complex component 7 (COG7)
      cd13736
      Location:473641
      SPRY_PRY_TRIM25; PRY/SPRY domain in tripartite motif-containing domain 25 (TRIM25)
      cl00788
      Location:342451
      MttA_Hcf106; mttA/Hcf106 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      74310024..74328473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)