EXOC5 exocyst complex component 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: EXOC5provided by HGNC
Official Full Name: exocyst complex component 5provided by HGNC
Primary source: HGNC:HGNC:10696
See related: Ensembl:ENSG00000070367 MIM:604469; AllianceGenome:HGNC:10696
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SEC10; HSEC10; SEC10P; PRO1912; SEC10L1
Summary: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 17.5), brain (RPKM 9.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q22.3

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (57200507..57268905, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (51406949..51475352, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (57667225..57735623, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The EXOC5 knockdown increases ARF6 levels and decreases EPS8L2 levels, and that EXOC5 overexpression increases EPS8L2.
Title: Primary cilia and the exocyst are linked to urinary extracellular vesicle production and content.
show that EXOC5 mRNA almost completely rescues the ciliary phenotypes in exoc5-mutant zebrafish, unlike the EXOC5CTS-m mRNA, which could not efficiently rescue the phenotypes
Title: The exocyst acting through the primary cilium is necessary for renal ciliogenesis, cystogenesis, and tubulogenesis.
These data confirm that the exocyst is preferentially involved in basolateral protein translation and translocation, and may well act through the phosphorylation of Sec61beta.
Title: Exocyst Sec10 is involved in basolateral protein translation and translocation in the endoplasmic reticulum.
Suggest that the exocyst sec10, acting through EGFR, endocytosis, and the MAPK pathway is a candidate therapeutic target for acute kidney injury.
Title: Exocyst Sec10 protects renal tubule cells from injury by EGFR/MAPK activation and effects on endocytosis.
Exocyst Sec10 overexpression reduces damage to tubular epithelial barriers caused by hydrogen peroxide and speeds the recovery of normal epithelial barrier function after such an injury.
Title: Exocyst Sec10 protects epithelial barrier integrity and enhances recovery following oxidative stress, by activation of the MAPK pathway.
The exocyst protein Sec10 regulates primary ciliogenesis.
Title: The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association between single-nucleotide polymorphisms in the SEC8L1 gene, which encodes a subunit of the exocyst complex, and rheumatoid arthritis in a Japanese population.
Data show that GTP-bound ARF6 interacts with Sec10, a subunit of the exocyst complex involved in docking of vesicles with the plasma membrane.
Title: ARF6 controls post-endocytic recycling through its downstream exocyst complex effector.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH17456 (e-PCR)
- UniSTS:68101

RH45179 (e-PCR)
- UniSTS:46626

SHGC-59490 (e-PCR)
- UniSTS:92233

RH69869 (e-PCR)
- UniSTS:74853

RH44844 (e-PCR)
- UniSTS:3715

SHGC-32913 (e-PCR)
- UniSTS:46211

D4S2497E (e-PCR)
- UniSTS:150961

SGC34266 (e-PCR)
- UniSTS:39611

SEC10L1__6912 (e-PCR)
- UniSTS:471754

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in establishment of planar polarity	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane fission	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in non-motile cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in post-Golgi vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle docking involved in exocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle tethering involved in exocytosis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	NAS Non-traceable Author Statement more info	PubMed
located_in midbody	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: exocyst complex component 5

Names: SEC10-like 1; exocyst complex component Sec10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.