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    RBBP9 RB binding protein 9, serine hydrolase [ Homo sapiens (human) ]

    Gene ID: 10741, updated on 28-Oct-2024

    Summary

    Official Symbol
    RBBP9provided by HGNC
    Official Full Name
    RB binding protein 9, serine hydrolaseprovided by HGNC
    Primary source
    HGNC:HGNC:9892
    See related
    Ensembl:ENSG00000089050 MIM:602908; AllianceGenome:HGNC:9892
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BOG; RBBP10
    Summary
    The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 16.2), kidney (RPKM 8.1) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RBBP9 in Genome Data Viewer
    Location:
    20p11.23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (18486540..18497225, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (18537660..18548351, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18467184..18477869, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA polymerase III subunit F Neighboring gene microRNA 3192 Neighboring gene ribosomal protein L21 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:18477654-18478218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17591 Neighboring gene ribosomal protein S19 pseudogene 1 Neighboring gene SEC23 homolog B, COPII coat complex component Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:18504796-18505995

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC9236

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nematode IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in type II pneumocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    serine hydrolase RBBP9
    Names
    B5T overexpressed gene protein
    RBBP-10
    RBBP-9
    putative hydrolase RBBP9
    retinoblastoma-binding protein 10
    retinoblastoma-binding protein 9
    retinoma-binding protein 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006606.3NP_006597.2  serine hydrolase RBBP9

      See identical proteins and their annotated locations for NP_006597.2

      Status: REVIEWED

      Source sequence(s)
      AL121893
      Consensus CDS
      CCDS13136.1
      UniProtKB/Swiss-Prot
      D3DW31, O75884, Q5JPH9, Q9H1D8
      Related
      ENSP00000336866.4, ENST00000337227.9
      Conserved Domains (1) summary
      cl21494
      Location:8173
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      18486540..18497225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      18537660..18548351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153328.1: Suppressed sequence

      Description
      NM_153328.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.