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    U2SURP U2 snRNP associated SURP domain containing [ Homo sapiens (human) ]

    Gene ID: 23350, updated on 28-Oct-2024

    Summary

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    Official Symbol
    U2SURPprovided by HGNC
    Official Full Name
    U2 snRNP associated SURP domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:30855
    See related
    Ensembl:ENSG00000163714 MIM:617849; AllianceGenome:HGNC:30855
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SR140; fSAPa
    Summary
    Enables RNA binding activity. Predicted to be involved in RNA processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 18.6), lymph node (RPKM 15.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See U2SURP in Genome Data Viewer
    Location:
    3q23
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (143001570..143060725)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (145748812..145808123)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (142720412..142779567)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:142677150-142678349 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:142681545-142681730 Neighboring gene progestin and adipoQ receptor family member 9 Neighboring gene PAQR9 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:142717850-142718850 Neighboring gene uncharacterized LOC100289361 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:142719850-142720849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20647 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:142791070-142791852 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:142792635-142793416 Neighboring gene uncharacterized LOC105374138 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4297 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:142837669-142838170 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:142838171-142838670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14794 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:142839329-142839970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:142840613-142841254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20651 Neighboring gene carbohydrate sulfotransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MYC-driven U2SURP regulates alternative splicing of SAT1 to promote triple-negative breast cancer progression. Deng L, et al. Cancer Lett, 2023 Apr 28. PMID 36907504
    2. U2-related proteins CHERP and SR140 contribute to colorectal tumorigenesis via alternative splicing regulation. Wang Q, et al. Int J Cancer, 2019 Nov 15. PMID 30977118
    3. Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways. Gilmore-Hebert M, et al. Mol Cancer Res, 2010 Oct. PMID 20858735, Free PMC Article
    4. LncRNA H19 Regulates Breast Cancer DNA Damage Response and Sensitivity to PARP Inhibitors via Binding to ILF2. Zhao J, et al. Int J Mol Sci, 2023 May 23. PMID 37298108, Free PMC Article
    5. Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex. Roboti P, et al. J Cell Sci, 2022 May 1. PMID 35543156, Free PMC Article

    See all (150) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of HIV-1 Tat upregulates the abundance of U2 snRNP-associated SURP domain containing (U2SURP) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0332, MGC133197

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U2 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    U2 snRNP-associated SURP motif-containing protein
    Names
    140 kDa Ser/Arg-rich domain protein
    Ser/Arg-rich domain protein, 140 kDa
    U2-associated SR140 protein
    U2-associated protein SR140
    functional spliceosome-associated protein a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080415.2 → NP_001073884.1  U2 snRNP-associated SURP motif-containing protein isoform 1

      See identical proteins and their annotated locations for NP_001073884.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC018450, AC026304
      Consensus CDS
      CCDS46928.1
      UniProtKB/Swiss-Prot
      A0PJ60, O15042, Q0D2M1, Q2NKQ7, Q9BR70
      Related
      ENSP00000418563.1, ENST00000473835.7
      Conserved Domains (5) summary
      smart00582
      Location:541 → 676
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
      COG0724
      Location:156 → 352
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam01805
      Location:429 → 480
      Surp; Surp module
      cd12223
      Location:273 → 356
      RRM_SR140; RNA recognition motif (RRM) found in U2-associated protein SR140 and similar proteins
      cd21370
      Location:836 → 884
      cwf21_SR140; cwf21 domain found in U2-associated protein SR140 and similar proteins

    2. NM_001320219.2 → NP_001307148.1  U2 snRNP-associated SURP motif-containing protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC018450, BC006474, BC111692
      UniProtKB/Swiss-Prot
      O15042
      Related
      ENSP00000422011.1, ENST00000493598.6
      Conserved Domains (5) summary
      smart00582
      Location:540 → 675
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
      COG0724
      Location:156 → 351
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam01805
      Location:428 → 479
      Surp; Surp module
      cd12223
      Location:272 → 355
      RRM_SR140; RNA recognition motif (RRM) found in U2-associated protein SR140 and similar proteins
      cd21370
      Location:835 → 883
      cwf21_SR140; cwf21 domain found in U2-associated protein SR140 and similar proteins

    3. NM_001320220.2 → NP_001307149.1  U2 snRNP-associated SURP motif-containing protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC018450, BC111692
      UniProtKB/Swiss-Prot
      O15042
      Conserved Domains (3) summary
      smart00582
      Location:132 → 267
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
      pfam01805
      Location:20 → 71
      Surp; Surp module
      cd21370
      Location:427 → 475
      cwf21_SR140; cwf21 domain found in U2-associated protein SR140 and similar proteins

    4. NM_001320222.2 → NP_001307151.1  U2 snRNP-associated SURP motif-containing protein isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC018450, BC028110, BC111692
      UniProtKB/Swiss-Prot
      O15042
      Conserved Domains (3) summary
      smart00582
      Location:108 → 243
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
      pfam01805
      Location:1 → 47
      Surp; Surp module
      pfam08312
      Location:410 → 451
      cwf21; cwf21 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      143001570..143060725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      145748812..145808123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15042.2 GenPept UniProtKB/Swiss-Prot:O15042

    Gene LinkOut

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