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    PBRM1 polybromo 1 [ Homo sapiens (human) ]

    Gene ID: 55193, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PBRM1provided by HGNC
    Official Full Name
    polybromo 1provided by HGNC
    Primary source
    HGNC:HGNC:30064
    See related
    Ensembl:ENSG00000163939 MIM:606083; AllianceGenome:HGNC:30064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PB1; RCC; BAF180; SMARCH1
    Summary
    This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]
    Expression
    Ubiquitous expression in thyroid (RPKM 10.3), ovary (RPKM 8.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PBRM1 in Genome Data Viewer
    Location:
    3p21.1
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (52545367..52685913, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (52578272..52718824, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52579383..52719929, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene stabilin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14445 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14448 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:52570940-52571473 Neighboring gene 5'-nucleotidase domain containing 2 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 5 Neighboring gene RNA, U6 small nuclear 856, pseudogene Neighboring gene RNA, U6atac small nuclear 16, pseudogene Neighboring gene MPRA-validated peak4655 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:52699923-52700424 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:52700425-52700924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19944 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:52719523-52720211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19945 Neighboring gene small nucleolar RNA, C/D box 136 Neighboring gene small nucleolar RNA, C/D box 19 Neighboring gene G protein nucleolar 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Role of PB1 Domain Proteins in Endothelial Cell Dysfunction and Disease. Burke RM, et al. Antioxid Redox Signal, 2015 May 10. PMID 25686626
    2. Thermodynamic analysis of acetylation-dependent Pb1 bromodomain-histone H3 interactions. Thompson M, et al. Anal Biochem, 2008 Mar 15. PMID 18191465, Free PMC Article
    3. Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. McMahon FJ, et al. Nat Genet, 2010 Feb. PMID 20081856, Free PMC Article
    4. PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner. Zhou M, et al. Cancer Immunol Res, 2022 Mar 1. PMID 35013001, Free PMC Article
    5. PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation. Gu X, et al. Cell Rep, 2021 Sep 21. PMID 34551289, Free PMC Article

    See all (218) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression.
      Title: Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression.
    2. Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation.
      Title: Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation.
    3. Relationship between body composition and PBRM1 mutations in clear cell renal cell carcinoma: a propensity score matching analysis.
      Title: Relationship between body composition and PBRM1 mutations in clear cell renal cell carcinoma: a propensity score matching analysis.
    4. PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-kappaB pathway in clear cell renal cell carcinoma.
      Title: PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma.
    5. PBRM1 bromodomains associate with RNA to facilitate chromatin association.
      Title: PBRM1 bromodomains associate with RNA to facilitate chromatin association.
    6. MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer.
      Title: MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer.
    7. PBRM1, SETD2 and BAP1 - the trinity of 3p in clear cell renal cell carcinoma.
      Title: PBRM1, SETD2 and BAP1 - the trinity of 3p in clear cell renal cell carcinoma.
    8. Nonsmall cell lung cancer carrying PBRM1 mutation suggests an immunologically cold phenotype leading to immunotherapy failure even with high TMB.
      Title: Non‑small cell lung cancer carrying PBRM1 mutation suggests an immunologically cold phenotype leading to immunotherapy failure even with high TMB.
    9. Interrogating the Significance of PARP1 Expression and PBRM1 Mutation as Biomarkers for Predicting the Response to Atezolizumab plus Bevacizumab or to Sunitinib in Patients with Clear Cell Renal Cell Carcinoma.
      Title: Interrogating the Significance of PARP1 Expression and PBRM1 Mutation as Biomarkers for Predicting the Response to Atezolizumab plus Bevacizumab or to Sunitinib in Patients with Clear Cell Renal Cell Carcinoma.
    10. PBRM1 presents a potential prognostic marker and therapeutic target in duodenal papillary carcinoma.
      Title: PBRM1 presents a potential prognostic marker and therapeutic target in duodenal papillary carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (81)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Nonpapillary renal cell carcinoma
    MedGen: CN074294 OMIM: 144700 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
    EBI GWAS Catalog
    Genome-wide association of mood-incongruent psychotic bipolar disorder.
    EBI GWAS Catalog
    Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.
    EBI GWAS Catalog
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.
    EBI GWAS Catalog
    Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat BAF180 is involved in HIV-1 Tat-dependent HIV promoter activity. BAF180 has no effect on LTR activation by HIV-1 Tat K50,51R mutant PubMed
    tat Most of the components of the SWI2/SNF2 chromatin remodeling complex (BRG1/BRM, BAF250, BAF180, BAF170, BAF155, BAF60a, BAF53A, actin and InI) except BRM, BAF155 and BAF57, are identified to interact with HIV-1 Tat in Jurkat cell PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156155, MGC156156

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in chromatin remodeling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of T cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of myoblast differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of G0 to G1 transition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of nucleotide-excision repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RSC-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RSC-type complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nuclear chromosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nuclear matrix NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein polybromo-1
    Names
    BRG1-associated factor 180
    polybromo-1D

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032108.1 RefSeqGene

      Range
      4938..145484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001350074.2 → NP_001337003.1  protein polybromo-1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes the longest isoform (5). Variants 5 and 9 encode the same isoform (5).
      Source sequence(s)
      AC104446, AF177387, AK001507, BC129935, CA438315, CD691117
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:694 → 798
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:203 → 305
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:555 → 658
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:404 → 505
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:811 → 918
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1416 → 1465
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:993 → 1110
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    2. NM_001350075.2 → NP_001337004.1  protein polybromo-1 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, uses a downstream start codon and contains multiple coding region differences, compared to variant 5. It encodes isoform 6, which is shorter than isoform 5.
      Source sequence(s)
      AC104446, AF177387, AK001507, BC115011, BF592839, CA438315
      Consensus CDS
      CCDS87087.1
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:658 → 762
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:519 → 622
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:383 → 484
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:775 → 882
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1380 → 1429
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:957 → 1074
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    3. NM_001350076.2 → NP_001337005.1  protein polybromo-1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and contains an alternate in-frame splice site in the 3' coding region, compared to variant 5. It encodes isoform 7, which is shorter than isoform 5.
      Source sequence(s)
      AC104446, AF177387, AI392948, AK001507, BC129934, CA438315, DA801725
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:694 → 798
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:203 → 305
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:555 → 658
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:404 → 505
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:811 → 918
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1415 → 1464
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:992 → 1109
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    4. NM_001350077.2 → NP_001337006.1  protein polybromo-1 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 5. It encodes isoform 8, which is shorter than isoform 5.
      Source sequence(s)
      AA724453, AC104446, AF177387, AK001507, BC129935, CA438315, CD691117, DA801725
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:691 → 795
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:200 → 302
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:552 → 655
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:401 → 502
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:62 → 174
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:808 → 915
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1413 → 1462
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:990 → 1107
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    5. NM_001350078.2 → NP_001337007.1  protein polybromo-1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 5. Variants 5 and 9 encode the same isoform (5).
      Source sequence(s)
      AC104446, AF225872, AI392948, AK001507, BC129935, CA438315, DA801725
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:694 → 798
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:203 → 305
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:555 → 658
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:404 → 505
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:811 → 918
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1416 → 1465
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:993 → 1110
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    6. NM_001350079.2 → NP_001337008.1  protein polybromo-1 isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 5. It encodes isoform 9, which is shorter than isoform 5.
      Source sequence(s)
      AC104446, AF225872, AK001507, BF592839, CA438315, DA801725
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (9) summary
      cd05515
      Location:679 → 783
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:203 → 305
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:540 → 643
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:404 → 505
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:796 → 903
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1376 → 1425
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:1151 → 1269
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
      cl02608
      Location:978 → 1070
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

    7. NM_001366070.2 → NP_001352999.1  protein polybromo-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:694 → 798
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:203 → 305
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:555 → 658
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:404 → 505
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:811 → 918
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1416 → 1465
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:993 → 1110
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    8. NM_001366071.2 → NP_001353000.1  protein polybromo-1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (9) summary
      cd05515
      Location:679 → 783
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:203 → 305
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:540 → 643
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:404 → 505
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:796 → 903
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1401 → 1465
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:978 → 1095
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
      pfam11593
      Location:1445 → 1529
      Med3; Mediator complex subunit 3 fungal

    9. NM_001366072.2 → NP_001353001.1  protein polybromo-1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:679 → 783
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:203 → 305
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:540 → 643
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:404 → 505
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:796 → 903
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1401 → 1450
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:978 → 1095
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    10. NM_001366073.2 → NP_001353002.1  protein polybromo-1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:676 → 780
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:200 → 302
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:537 → 640
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:401 → 502
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:62 → 174
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:793 → 900
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1398 → 1447
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:975 → 1092
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    11. NM_001366074.2 → NP_001353003.1  protein polybromo-1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:675 → 779
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:199 → 301
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:536 → 639
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:400 → 501
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:61 → 173
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:792 → 899
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1397 → 1446
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:974 → 1091
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    12. NM_001366075.2 → NP_001353004.1  protein polybromo-1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (9) summary
      cd05515
      Location:694 → 798
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:203 → 305
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:555 → 658
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:404 → 505
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:811 → 918
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1391 → 1440
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:1166 → 1284
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
      cl02608
      Location:993 → 1085
      BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

    13. NM_001366076.2 → NP_001353005.1  protein polybromo-1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:659 → 763
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:200 → 302
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:520 → 623
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:369 → 470
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:62 → 174
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:776 → 883
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1381 → 1430
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:958 → 1075
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    14. NM_001394867.1 → NP_001381796.1  protein polybromo-1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS93286.1
      UniProtKB/Swiss-Prot
      A1L381, A1L382, A4FUJ7, Q1RMD1, Q1RMD2, Q86U86, Q96MS2, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:658 → 762
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:519 → 622
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:383 → 484
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:775 → 882
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1380 → 1444
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:957 → 1074
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    15. NM_001394868.1 → NP_001381797.1  protein polybromo-1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS93286.1
      UniProtKB/Swiss-Prot
      A1L381, A1L382, A4FUJ7, Q1RMD1, Q1RMD2, Q86U86, Q96MS2, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:658 → 762
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:519 → 622
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:383 → 484
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:775 → 882
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1380 → 1444
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:957 → 1074
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    16. NM_001394869.1 → NP_001381798.1  protein polybromo-1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS93286.1
      UniProtKB/Swiss-Prot
      A1L381, A1L382, A4FUJ7, Q1RMD1, Q1RMD2, Q86U86, Q96MS2, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:658 → 762
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:519 → 622
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:383 → 484
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:775 → 882
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1380 → 1444
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:957 → 1074
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    17. NM_001394870.1 → NP_001381799.1  protein polybromo-1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:676 → 780
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:200 → 302
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:537 → 640
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:401 → 502
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:62 → 174
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:793 → 900
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1398 → 1447
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:975 → 1092
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    18. NM_001394871.1 → NP_001381800.1  protein polybromo-1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (9) summary
      cd05515
      Location:658 → 762
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:519 → 622
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:383 → 484
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:775 → 882
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      PRK06302
      Location:1444 → 1509
      PRK06302; acetyl-CoA carboxylase biotin carboxyl carrier protein
      cd00084
      Location:1380 → 1444
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:957 → 1074
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    19. NM_001394872.1 → NP_001381801.1  protein polybromo-1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS87087.1
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:658 → 762
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:519 → 622
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:383 → 484
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:775 → 882
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1380 → 1429
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:957 → 1074
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    20. NM_001394873.1 → NP_001381802.1  protein polybromo-1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:658 → 762
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:519 → 622
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:383 → 484
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:775 → 882
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1379 → 1428
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:956 → 1073
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    21. NM_001394874.1 → NP_001381803.1  protein polybromo-1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:658 → 762
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:519 → 622
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:383 → 484
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:775 → 882
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1379 → 1428
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:956 → 1073
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    22. NM_001394875.1 → NP_001381804.1  protein polybromo-1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS2860.1
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:658 → 762
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:519 → 622
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:383 → 484
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:775 → 882
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1380 → 1429
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:957 → 1074
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    23. NM_001394876.1 → NP_001381805.1  protein polybromo-1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:658 → 762
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:519 → 622
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:383 → 484
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:775 → 882
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1379 → 1428
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:956 → 1073
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    24. NM_001394877.1 → NP_001381806.1  protein polybromo-1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:658 → 762
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:519 → 622
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:383 → 484
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:775 → 882
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1379 → 1428
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:956 → 1073
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    25. NM_001394878.1 → NP_001381807.1  protein polybromo-1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:646 → 750
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:507 → 610
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:371 → 472
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:763 → 870
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1368 → 1417
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:945 → 1062
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
      cl02556
      Location:203 → 287
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    26. NM_001394879.1 → NP_001381808.1  protein polybromo-1 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:626 → 730
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:487 → 590
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:351 → 452
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:743 → 850
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1348 → 1412
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:925 → 1042
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    27. NM_001394880.1 → NP_001381809.1  protein polybromo-1 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Conserved Domains (2) summary
      cd05517
      Location:203 → 305
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...

    28. NM_001394881.1 → NP_001381810.1  protein polybromo-1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Conserved Domains (2) summary
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...

    29. NM_001400470.1 → NP_001387399.1  protein polybromo-1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS93286.1
      UniProtKB/Swiss-Prot
      A1L381, A1L382, A4FUJ7, Q1RMD1, Q1RMD2, Q86U86, Q96MS2, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314

    30. NM_001400471.1 → NP_001387400.1  protein polybromo-1 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    31. NM_001400472.1 → NP_001387401.1  protein polybromo-1 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    32. NM_001400473.1 → NP_001387402.1  protein polybromo-1 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    33. NM_001400474.1 → NP_001387403.1  protein polybromo-1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS87087.1

    34. NM_001400475.1 → NP_001387404.1  protein polybromo-1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS87087.1

    35. NM_001400479.1 → NP_001387408.1  protein polybromo-1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS87087.1

    36. NM_001400481.1 → NP_001387410.1  protein polybromo-1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    37. NM_001400484.1 → NP_001387413.1  protein polybromo-1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS93285.1

    38. NM_001400487.1 → NP_001387416.1  protein polybromo-1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS2859.1

    39. NM_001400490.1 → NP_001387419.1  protein polybromo-1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    40. NM_001400496.1 → NP_001387425.1  protein polybromo-1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS2860.1

    41. NM_001400500.1 → NP_001387429.1  protein polybromo-1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS2860.1

    42. NM_001400501.1 → NP_001387430.1  protein polybromo-1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS2860.1

    43. NM_001400504.1 → NP_001387433.1  protein polybromo-1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    44. NM_001405552.1 → NP_001392481.1  protein polybromo-1 isoform 52

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    45. NM_001405553.1 → NP_001392482.1  protein polybromo-1 isoform 55

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    46. NM_001405554.1 → NP_001392483.1  protein polybromo-1 isoform 53

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    47. NM_001405555.1 → NP_001392484.1  protein polybromo-1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Related
      ENSP00000338302.4, ENST00000337303.8

    48. NM_001405556.1 → NP_001392485.1  protein polybromo-1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Related
      ENSP00000386593.1, ENST00000409057.5

    49. NM_001405557.1 → NP_001392486.1  protein polybromo-1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    50. NM_001405558.1 → NP_001392487.1  protein polybromo-1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    51. NM_001405559.1 → NP_001392488.1  protein polybromo-1 isoform 54

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    52. NM_001405560.1 → NP_001392489.1  protein polybromo-1 isoform 71

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    53. NM_001405561.1 → NP_001392490.1  protein polybromo-1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    54. NM_001405563.1 → NP_001392492.1  protein polybromo-1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    55. NM_001405564.1 → NP_001392493.1  protein polybromo-1 isoform 64

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    56. NM_001405565.1 → NP_001392494.1  protein polybromo-1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Related
      ENSP00000386529.1, ENST00000410007.5

    57. NM_001405566.1 → NP_001392495.1  protein polybromo-1 isoform 78

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    58. NM_001405567.1 → NP_001392496.1  protein polybromo-1 isoform 51

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    59. NM_001405568.1 → NP_001392497.1  protein polybromo-1 isoform 58

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    60. NM_001405569.1 → NP_001392498.1  protein polybromo-1 isoform 59

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    61. NM_001405570.1 → NP_001392499.1  protein polybromo-1 isoform 50

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    62. NM_001405571.1 → NP_001392500.1  protein polybromo-1 isoform 57

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    63. NM_001405572.1 → NP_001392501.1  protein polybromo-1 isoform 67

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    64. NM_001405573.1 → NP_001392502.1  protein polybromo-1 isoform 68

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    65. NM_001405574.1 → NP_001392503.1  protein polybromo-1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    66. NM_001405575.1 → NP_001392504.1  protein polybromo-1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    67. NM_001405576.1 → NP_001392505.1  protein polybromo-1 isoform 70

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    68. NM_001405577.1 → NP_001392506.1  protein polybromo-1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    69. NM_001405578.1 → NP_001392507.1  protein polybromo-1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    70. NM_001405579.1 → NP_001392508.1  protein polybromo-1 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    71. NM_001405580.1 → NP_001392509.1  protein polybromo-1 isoform 69

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    72. NM_001405581.1 → NP_001392510.1  protein polybromo-1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/Swiss-Prot
      A1L381, A1L382, A4FUJ7, Q1RMD1, Q1RMD2, Q86U86, Q96MS2, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314
      Related
      ENSP00000296302.7, ENST00000296302.11

    73. NM_001405582.1 → NP_001392511.1  protein polybromo-1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Related
      ENSP00000349213.4, ENST00000356770.8

    74. NM_001405583.1 → NP_001392512.1  protein polybromo-1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    75. NM_001405584.1 → NP_001392513.1  protein polybromo-1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Related
      ENSP00000386643.3, ENST00000409114.7

    76. NM_001405585.1 → NP_001392514.1  protein polybromo-1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    77. NM_001405586.1 → NP_001392515.1  protein polybromo-1 isoform 83

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    78. NM_001405587.1 → NP_001392516.1  protein polybromo-1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    79. NM_001405588.1 → NP_001392517.1  protein polybromo-1 isoform 54

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    80. NM_001405589.1 → NP_001392518.1  protein polybromo-1 isoform 51

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    81. NM_001405590.1 → NP_001392519.1  protein polybromo-1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    82. NM_001405591.1 → NP_001392520.1  protein polybromo-1 isoform 61

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    83. NM_001405592.1 → NP_001392521.1  protein polybromo-1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    84. NM_001405593.1 → NP_001392522.1  protein polybromo-1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    85. NM_001405594.1 → NP_001392523.1  protein polybromo-1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/Swiss-Prot
      A1L381, A1L382, A4FUJ7, Q1RMD1, Q1RMD2, Q86U86, Q96MS2, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314

    86. NM_001405595.1 → NP_001392524.1  protein polybromo-1 isoform 62

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    87. NM_001405596.1 → NP_001392525.1  protein polybromo-1 isoform 77

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    88. NM_001405597.1 → NP_001392526.1  protein polybromo-1 isoform 63

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    89. NM_001405598.1 → NP_001392527.1  protein polybromo-1 isoform 49

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    90. NM_001405599.1 → NP_001392528.1  protein polybromo-1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    91. NM_001405600.1 → NP_001392529.1  protein polybromo-1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    92. NM_001405601.1 → NP_001392530.1  protein polybromo-1 isoform 48

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      A0A9L9PXL4

    93. NM_001405602.1 → NP_001392531.1  protein polybromo-1 isoform 84

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    94. NM_001405603.1 → NP_001392532.1  protein polybromo-1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/Swiss-Prot
      A1L381, A1L382, A4FUJ7, Q1RMD1, Q1RMD2, Q86U86, Q96MS2, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314

    95. NM_001405604.1 → NP_001392533.1  protein polybromo-1 isoform 82

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    96. NM_001405605.1 → NP_001392534.1  protein polybromo-1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    97. NM_001405606.1 → NP_001392535.1  protein polybromo-1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    98. NM_001405607.1 → NP_001392536.1  protein polybromo-1 isoform 48

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      UniProtKB/TrEMBL
      A0A9L9PXL4
      Related
      ENSP00000516722.1, ENST00000707071.1

    99. NM_001405608.1 → NP_001392537.1  protein polybromo-1 isoform 74

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    100. NM_001405609.1 → NP_001392538.1  protein polybromo-1 isoform 66

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    101. NM_001405610.1 → NP_001392539.1  protein polybromo-1 isoform 72

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Related
      ENSP00000387775.1, ENST00000423351.5

    102. NM_001405611.1 → NP_001392540.1  protein polybromo-1 isoform 73

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    103. NM_001405612.1 → NP_001392541.1  protein polybromo-1 isoform 76

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215
      Related
      ENSP00000397662.1, ENST00000446103.5

    104. NM_001405613.1 → NP_001392542.1  protein polybromo-1 isoform 80

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    105. NM_001405614.1 → NP_001392543.1  protein polybromo-1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    106. NM_001405615.1 → NP_001392544.1  protein polybromo-1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    107. NM_001405616.1 → NP_001392545.1  protein polybromo-1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    108. NM_001405617.1 → NP_001392546.1  protein polybromo-1 isoform 81

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    109. NM_001405618.1 → NP_001392547.1  protein polybromo-1 isoform 81

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    110. NM_001405619.1 → NP_001392548.1  protein polybromo-1 isoform 79

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    111. NM_001405620.1 → NP_001392549.1  protein polybromo-1 isoform 81

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    112. NM_001405621.1 → NP_001392550.1  protein polybromo-1 isoform 79

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    113. NM_001405622.1 → NP_001392551.1  protein polybromo-1 isoform 55

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    114. NM_001405623.1 → NP_001392552.1  protein polybromo-1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    115. NM_001405624.1 → NP_001392553.1  protein polybromo-1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    116. NM_001405625.1 → NP_001392554.1  protein polybromo-1 isoform 75

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    117. NM_001405626.1 → NP_001392555.1  protein polybromo-1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    118. NM_001405627.1 → NP_001392556.1  protein polybromo-1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    119. NM_001405628.1 → NP_001392557.1  protein polybromo-1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    120. NM_001405629.1 → NP_001392558.1  protein polybromo-1 isoform 51

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    121. NM_001405630.1 → NP_001392559.1  protein polybromo-1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    122. NM_001405631.1 → NP_001392560.1  protein polybromo-1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    123. NM_001405632.1 → NP_001392561.1  protein polybromo-1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    124. NM_001405633.1 → NP_001392562.1  protein polybromo-1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    125. NM_001405634.1 → NP_001392563.1  protein polybromo-1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    126. NM_001405635.1 → NP_001392564.1  protein polybromo-1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    127. NM_001405636.1 → NP_001392565.1  protein polybromo-1 isoform 64

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    128. NM_001405637.1 → NP_001392566.1  protein polybromo-1 isoform 60

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    129. NM_001405638.1 → NP_001392567.1  protein polybromo-1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    130. NM_001405639.1 → NP_001392568.1  protein polybromo-1 isoform 54

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    131. NM_001405640.1 → NP_001392569.1  protein polybromo-1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    132. NM_001405641.1 → NP_001392570.1  protein polybromo-1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    133. NM_001405642.1 → NP_001392571.1  protein polybromo-1 isoform 71

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    134. NM_001405643.1 → NP_001392572.1  protein polybromo-1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    135. NM_018313.5 → NP_060783.3  protein polybromo-1 isoform 2

      See identical proteins and their annotated locations for NP_060783.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains multiple differences in the coding region, compared to variant 5. It encodes isoform 2, which is shorter than isoform 5. Variants 2 and 4 encode isoforms that are of the same length, but have distinct protein sequences.
      Source sequence(s)
      AC104446, AF177387, AF197569, BE672944, BG778619, BU171600, BU619411, CA438315, CV573455, DA039085
      Consensus CDS
      CCDS43099.1
      UniProtKB/TrEMBL
      E7EVG2
      Related
      ENSP00000378307.3, ENST00000394830.7
      Conserved Domains (9) summary
      cd05515
      Location:658 → 762
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:519 → 622
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:383 → 484
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:775 → 882
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1328 → 1377
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:1130 → 1248
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
      cl02608
      Location:957 → 1049
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

    136. NM_181042.5 → NP_851385.1  protein polybromo-1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) This variant (2) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 5. It encodes isoform 4, which is shorter than isoform 5. Variants 2 and 4 encode isoforms that are the same length, but have distinct protein sequences.
      Source sequence(s)
      AC104446, AC112215
      Consensus CDS
      CCDS2860.1
      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:658 → 762
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:182 → 284
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:519 → 622
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:383 → 484
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:44 → 156
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:775 → 882
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1380 → 1429
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:957 → 1074
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    RNA

    1. NR_174502.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    2. NR_175959.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC104446, AC112215

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      52545367..52685913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448460.1 → XP_047304416.1  protein polybromo-1 isoform X19

    2. XM_047448462.1 → XP_047304418.1  protein polybromo-1 isoform X20

    3. XM_047448449.1 → XP_047304405.1  protein polybromo-1 isoform X9

    4. XM_017006734.3 → XP_016862223.1  protein polybromo-1 isoform X8

      UniProtKB/TrEMBL
      E7EVG2

    5. XM_047448445.1 → XP_047304401.1  protein polybromo-1 isoform X4

    6. XM_017006744.2 → XP_016862233.1  protein polybromo-1 isoform X13

      UniProtKB/TrEMBL
      E7EVG2

    7. XM_024453619.2 → XP_024309387.1  protein polybromo-1 isoform X7

      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:691 → 795
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:200 → 302
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:552 → 655
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:401 → 502
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:62 → 174
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:808 → 915
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1413 → 1477
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:990 → 1107
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    8. XM_047448457.1 → XP_047304413.1  protein polybromo-1 isoform X17

    9. XM_017006741.3 → XP_016862230.1  protein polybromo-1 isoform X10

      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:679 → 783
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:203 → 305
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:540 → 643
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:404 → 505
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:796 → 903
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1401 → 1465
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:978 → 1095
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    10. XM_011533902.4 → XP_011532204.1  protein polybromo-1 isoform X5

      See identical proteins and their annotated locations for XP_011532204.1

      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:694 → 798
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:203 → 305
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:555 → 658
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:404 → 505
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:811 → 918
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1416 → 1480
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:993 → 1110
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    11. XM_017006725.2 → XP_016862214.1  protein polybromo-1 isoform X1

      UniProtKB/TrEMBL
      E7EVG2

    12. XM_047448455.1 → XP_047304411.1  protein polybromo-1 isoform X15

    13. XM_017006730.2 → XP_016862219.1  protein polybromo-1 isoform X3

      UniProtKB/TrEMBL
      E7EVG2

    14. XM_047448447.1 → XP_047304403.1  protein polybromo-1 isoform X5

    15. XM_017006727.2 → XP_016862216.1  protein polybromo-1 isoform X1

      UniProtKB/TrEMBL
      E7EVG2

    16. XM_047448444.1 → XP_047304400.1  protein polybromo-1 isoform X4

    17. XM_047448448.1 → XP_047304404.1  protein polybromo-1 isoform X6

    18. XM_047448456.1 → XP_047304412.1  protein polybromo-1 isoform X16

    19. XM_047448446.1 → XP_047304402.1  protein polybromo-1 isoform X5

    20. XM_047448451.1 → XP_047304407.1  protein polybromo-1 isoform X12

    21. XM_047448443.1 → XP_047304399.1  protein polybromo-1 isoform X2

    22. XM_047448450.1 → XP_047304406.1  protein polybromo-1 isoform X11

    23. XM_047448442.1 → XP_047304398.1  protein polybromo-1 isoform X1

    24. XM_047448459.1 → XP_047304415.1  protein polybromo-1 isoform X18

    25. XM_047448453.1 → XP_047304409.1  protein polybromo-1 isoform X14

    26. XM_047448452.1 → XP_047304408.1  protein polybromo-1 isoform X13

    27. XM_017006731.2 → XP_016862220.1  protein polybromo-1 isoform X3

      UniProtKB/TrEMBL
      E7EVG2

    28. XM_017006742.2 → XP_016862231.1  protein polybromo-1 isoform X10

      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:679 → 783
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:203 → 305
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:540 → 643
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:404 → 505
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:796 → 903
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1401 → 1465
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:978 → 1095
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    29. XM_011533903.4 → XP_011532205.1  protein polybromo-1 isoform X5

      See identical proteins and their annotated locations for XP_011532205.1

      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:694 → 798
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:203 → 305
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:555 → 658
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:404 → 505
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:811 → 918
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1416 → 1480
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:993 → 1110
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    30. XM_017006728.2 → XP_016862217.1  protein polybromo-1 isoform X1

      UniProtKB/TrEMBL
      E7EVG2

    31. XM_047448454.1 → XP_047304410.1  protein polybromo-1 isoform X15

    32. XM_011533900.4 → XP_011532202.1  protein polybromo-1 isoform X5

      See identical proteins and their annotated locations for XP_011532202.1

      UniProtKB/TrEMBL
      E7EVG2
      Conserved Domains (8) summary
      cd05515
      Location:694 → 798
      Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05517
      Location:203 → 305
      Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05518
      Location:555 → 658
      Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05520
      Location:404 → 505
      Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05524
      Location:65 → 177
      Bromo_polybromo_I; Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd05526
      Location:811 → 918
      Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...
      cd00084
      Location:1416 → 1480
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd04717
      Location:993 → 1110
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

    33. XM_017006726.2 → XP_016862215.1  protein polybromo-1 isoform X1

      UniProtKB/TrEMBL
      E7EVG2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      52578272..52718824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347105.1 → XP_054203080.1  protein polybromo-1 isoform X19

    2. XM_054347106.1 → XP_054203081.1  protein polybromo-1 isoform X20

    3. XM_054347092.1 → XP_054203067.1  protein polybromo-1 isoform X9

    4. XM_054347091.1 → XP_054203066.1  protein polybromo-1 isoform X8

    5. XM_054347083.1 → XP_054203058.1  protein polybromo-1 isoform X4

    6. XM_054347097.1 → XP_054203072.1  protein polybromo-1 isoform X13

    7. XM_054347090.1 → XP_054203065.1  protein polybromo-1 isoform X7

    8. XM_054347103.1 → XP_054203078.1  protein polybromo-1 isoform X17

    9. XM_054347093.1 → XP_054203068.1  protein polybromo-1 isoform X10

    10. XM_054347086.1 → XP_054203061.1  protein polybromo-1 isoform X5

    11. XM_054347075.1 → XP_054203050.1  protein polybromo-1 isoform X1

    12. XM_054347101.1 → XP_054203076.1  protein polybromo-1 isoform X15

    13. XM_054347081.1 → XP_054203056.1  protein polybromo-1 isoform X3

    14. XM_054347088.1 → XP_054203063.1  protein polybromo-1 isoform X5

    15. XM_054347078.1 → XP_054203053.1  protein polybromo-1 isoform X1

    16. XM_054347082.1 → XP_054203057.1  protein polybromo-1 isoform X4

    17. XM_054347089.1 → XP_054203064.1  protein polybromo-1 isoform X6

    18. XM_054347102.1 → XP_054203077.1  protein polybromo-1 isoform X16

    19. XM_054347084.1 → XP_054203059.1  protein polybromo-1 isoform X5

    20. XM_054347096.1 → XP_054203071.1  protein polybromo-1 isoform X12

    21. XM_054347079.1 → XP_054203054.1  protein polybromo-1 isoform X2

    22. XM_054347095.1 → XP_054203070.1  protein polybromo-1 isoform X11

    23. XM_054347074.1 → XP_054203049.1  protein polybromo-1 isoform X1

    24. XM_054347104.1 → XP_054203079.1  protein polybromo-1 isoform X18

    25. XM_054347099.1 → XP_054203074.1  protein polybromo-1 isoform X14

    26. XM_054347098.1 → XP_054203073.1  protein polybromo-1 isoform X13

    27. XM_054347080.1 → XP_054203055.1  protein polybromo-1 isoform X3

    28. XM_054347094.1 → XP_054203069.1  protein polybromo-1 isoform X10

    29. XM_054347085.1 → XP_054203060.1  protein polybromo-1 isoform X5

    30. XM_054347076.1 → XP_054203051.1  protein polybromo-1 isoform X1

    31. XM_054347100.1 → XP_054203075.1  protein polybromo-1 isoform X15

    32. XM_054347087.1 → XP_054203062.1  protein polybromo-1 isoform X5

    33. XM_054347077.1 → XP_054203052.1  protein polybromo-1 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181041.1: Suppressed sequence

      Description
      NM_181041.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86U86.1 GenPept UniProtKB/Swiss-Prot:Q86U86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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