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    CTNNBIP1 catenin beta interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 56998, updated on 28-Oct-2024

    Summary

    Official Symbol
    CTNNBIP1provided by HGNC
    Official Full Name
    catenin beta interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:16913
    See related
    Ensembl:ENSG00000178585 MIM:607758; AllianceGenome:HGNC:16913
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ICAT
    Summary
    The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in skin (RPKM 77.0), esophagus (RPKM 25.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CTNNBIP1 in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9848276..9910269, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (9391187..9453193, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9908334..9970327, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Neighboring gene uncharacterized LOC124903839 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:9778914-9780113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9780296-9781272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9781273-9782247 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:9785121-9785329 Neighboring gene calsyntenin 1 Neighboring gene MPRA-validated peak58 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9846382-9846882 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9848516-9849304 Neighboring gene Sharpr-MPRA regulatory region 8161 Neighboring gene mitotic spindle organizing protein 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 232 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9883897-9884613 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 137 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9895719-9896320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9896321-9896920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9902151-9902692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9902693-9903232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9903774-9904313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9908375-9908876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 138 Neighboring gene uncharacterized LOC105376717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 139 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9911316-9912116 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9919701-9920595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9931412-9932340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9932341-9933268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 236 Neighboring gene uncharacterized LOC124903838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9943986-9944775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9946851-9947439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9960261-9960762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 239 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9970922-9971595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9971596-9972268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9987872-9988381 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9990871-9991370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9998882-9999382 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9999383-9999883 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:10002582-10003781 Neighboring gene leucine zipper and CTNNBIP1 domain containing Neighboring gene RN7SK pseudogene 269 Neighboring gene nicotinamide nucleotide adenylyltransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC15093

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables armadillo repeat domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription initiation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of monocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of vascular permeability involved in acute inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin destruction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of beta-catenin destruction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of beta-catenin-ICAT complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    beta-catenin-interacting protein 1
    Names
    beta-catenin-interacting protein ICAT
    inhibitor of beta-catenin and Tcf-4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029165.1 RefSeqGene

      Range
      4990..66983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001012329.2NP_001012329.1  beta-catenin-interacting protein 1

      See identical proteins and their annotated locations for NP_001012329.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL357140, CB995652
      Consensus CDS
      CCDS106.1
      UniProtKB/Swiss-Prot
      Q5T4V2, Q9NSA3
      Related
      ENSP00000383696.3, ENST00000400904.7
      Conserved Domains (1) summary
      pfam06384
      Location:179
      ICAT; Beta-catenin-interacting protein ICAT
    2. NM_020248.3NP_064633.1  beta-catenin-interacting protein 1

      See identical proteins and their annotated locations for NP_064633.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL357140, BI226022, CB995652
      Consensus CDS
      CCDS106.1
      UniProtKB/Swiss-Prot
      Q5T4V2, Q9NSA3
      Related
      ENSP00000366474.1, ENST00000377263.6
      Conserved Domains (1) summary
      pfam06384
      Location:179
      ICAT; Beta-catenin-interacting protein ICAT

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      9848276..9910269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425762.1XP_047281718.1  beta-catenin-interacting protein 1 isoform X1

    2. XM_047425765.1XP_047281721.1  beta-catenin-interacting protein 1 isoform X1

    3. XM_047425763.1XP_047281719.1  beta-catenin-interacting protein 1 isoform X1

    4. XM_047425770.1XP_047281726.1  beta-catenin-interacting protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5T4V2, Q9NSA3
    5. XM_047425766.1XP_047281722.1  beta-catenin-interacting protein 1 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      9391187..9453193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337777.1XP_054193752.1  beta-catenin-interacting protein 1 isoform X1

    2. XM_054337779.1XP_054193754.1  beta-catenin-interacting protein 1 isoform X1

    3. XM_054337778.1XP_054193753.1  beta-catenin-interacting protein 1 isoform X1

    4. XM_054337780.1XP_054193755.1  beta-catenin-interacting protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5T4V2, Q9NSA3
    5. XM_054337782.1XP_054193757.1  beta-catenin-interacting protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5T4V2, Q9NSA3
    6. XM_054337781.1XP_054193756.1  beta-catenin-interacting protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5T4V2, Q9NSA3