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    LRRC71 leucine rich repeat containing 71 [ Homo sapiens (human) ]

    Gene ID: 149499, updated on 10-Oct-2024

    Summary

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    Official Symbol
    LRRC71provided by HGNC
    Official Full Name
    leucine rich repeat containing 71provided by HGNC
    Primary source
    HGNC:HGNC:26556
    See related
    Ensembl:ENSG00000160838 AllianceGenome:HGNC:26556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C1orf92
    Expression
    Restricted expression toward testis (RPKM 8.7) See more
    Orthologs
    mouse all
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    Genomic context

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    See LRRC71 in Genome Data Viewer
    Location:
    1q23.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156920632..156941073)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (156057478..156077914)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156890424..156902886)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156811133-156811814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156811815-156812494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156814249-156814884 Neighboring gene Sharpr-MPRA regulatory region 5756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156830955-156831498 Neighboring gene insulin receptor related receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156836581-156837238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156844837-156845734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156862813-156863317 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:156865761-156866960 Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1441 Neighboring gene Rho guanine nucleotide exchange factor 11 Neighboring gene microRNA 765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1442 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156951350-156951542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156961673-156962173 Neighboring gene RNA, 7SL, cytoplasmic 612, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1443 Neighboring gene uncharacterized LOC102724222

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III. Maio N, et al. Cell Metab, 2017 Apr 4. PMID 28380382
    2. The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside. Sun X, et al. J Ginseng Res, 2022 Mar. PMID 35509820, Free PMC Article
    3. Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry. Wheat A, et al. Proc Natl Acad Sci U S A, 2021 Aug 10. PMID 34349018, Free PMC Article
    4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32884, FLJ77598, MGC45468

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 71
    Names
    leucine-rich repeat-containing protein C10orf92

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144702.3 → NP_653303.2  leucine-rich repeat-containing protein 71

      See identical proteins and their annotated locations for NP_653303.2

      Status: VALIDATED

      Source sequence(s)
      AK292342, AL356104, BC033790, BU689904
      Consensus CDS
      CCDS44249.1
      UniProtKB/Swiss-Prot
      Q8N4P6, Q96M24
      UniProtKB/TrEMBL
      A8K8H7
      Related
      ENSP00000336661.7, ENST00000337428.8
      Conserved Domains (2) summary
      cd00116
      Location:161 → 308
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:168 → 196
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156920632..156941073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000459.3 → XP_016855948.1  leucine-rich repeat-containing protein 71 isoform X7

    2. XM_047447397.1 → XP_047303353.1  leucine-rich repeat-containing protein 71 isoform X2

    3. XM_006711185.4 → XP_006711248.1  leucine-rich repeat-containing protein 71 isoform X2

      See identical proteins and their annotated locations for XP_006711248.1

      UniProtKB/TrEMBL
      A8K8H7
      Related
      ENST00000490146.5
      Conserved Domains (2) summary
      cd00116
      Location:134 → 281
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:141 → 169
      LRR_RI; leucine-rich repeat [structural motif]

    4. XM_005244926.4 → XP_005244983.1  leucine-rich repeat-containing protein 71 isoform X1

      UniProtKB/TrEMBL
      A8K8H7
      Conserved Domains (2) summary
      cd00116
      Location:161 → 308
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:168 → 196
      LRR_RI; leucine-rich repeat [structural motif]

    5. XM_006711186.4 → XP_006711249.1  leucine-rich repeat-containing protein 71 isoform X3

      UniProtKB/TrEMBL
      A8K8H7
      Conserved Domains (2) summary
      cd00116
      Location:161 → 308
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:168 → 196
      LRR_RI; leucine-rich repeat [structural motif]

    6. XM_006711187.4 → XP_006711250.1  leucine-rich repeat-containing protein 71 isoform X4

      UniProtKB/TrEMBL
      A8K8H7
      Conserved Domains (2) summary
      cd00116
      Location:161 → 308
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:168 → 196
      LRR_RI; leucine-rich repeat [structural motif]

    7. XM_005244927.4 → XP_005244984.1  leucine-rich repeat-containing protein 71 isoform X5

      Conserved Domains (2) summary
      cd00116
      Location:161 → 308
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:168 → 196
      LRR_RI; leucine-rich repeat [structural motif]

    8. XM_005244928.3 → XP_005244985.1  leucine-rich repeat-containing protein 71 isoform X6

      UniProtKB/TrEMBL
      A8K8H7
      Conserved Domains (2) summary
      cd00116
      Location:161 → 308
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:168 → 196
      LRR_RI; leucine-rich repeat [structural motif]

    9. XM_047447415.1 → XP_047303371.1  leucine-rich repeat-containing protein 71 isoform X9

    10. XM_011509241.3 → XP_011507543.1  leucine-rich repeat-containing protein 71 isoform X11

      Conserved Domains (2) summary
      cd00116
      Location:161 → 308
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:168 → 196
      LRR_RI; leucine-rich repeat [structural motif]

    11. XM_017000462.3 → XP_016855951.1  leucine-rich repeat-containing protein 71 isoform X10

      Conserved Domains (2) summary
      cd00116
      Location:9 → 93
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:9 → 34
      LRR_1; leucine-rich repeat [structural motif]

    12. XM_011509239.3 → XP_011507541.1  leucine-rich repeat-containing protein 71 isoform X8

      Conserved Domains (2) summary
      cd00116
      Location:9 → 122
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:11 → 31
      LRR_RI; leucine-rich repeat [structural motif]

    13. XM_047447420.1 → XP_047303376.1  leucine-rich repeat-containing protein 71 isoform X12

    14. XM_047447421.1 → XP_047303377.1  leucine-rich repeat-containing protein 71 isoform X13

    15. XM_011509240.4 → XP_011507542.1  leucine-rich repeat-containing protein 71 isoform X10

      See identical proteins and their annotated locations for XP_011507542.1

      Conserved Domains (2) summary
      cd00116
      Location:9 → 93
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:9 → 34
      LRR_1; leucine-rich repeat [structural motif]

    RNA

    1. XR_241072.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      156057478..156077914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334682.1 → XP_054190657.1  leucine-rich repeat-containing protein 71 isoform X7

    2. XM_054334677.1 → XP_054190652.1  leucine-rich repeat-containing protein 71 isoform X2

    3. XM_054334676.1 → XP_054190651.1  leucine-rich repeat-containing protein 71 isoform X2

    4. XM_054334675.1 → XP_054190650.1  leucine-rich repeat-containing protein 71 isoform X1

    5. XM_054334678.1 → XP_054190653.1  leucine-rich repeat-containing protein 71 isoform X3

    6. XM_054334679.1 → XP_054190654.1  leucine-rich repeat-containing protein 71 isoform X4

    7. XM_054334680.1 → XP_054190655.1  leucine-rich repeat-containing protein 71 isoform X5

    8. XM_054334681.1 → XP_054190656.1  leucine-rich repeat-containing protein 71 isoform X6

    9. XM_054334684.1 → XP_054190659.1  leucine-rich repeat-containing protein 71 isoform X9

    10. XM_054334688.1 → XP_054190663.1  leucine-rich repeat-containing protein 71 isoform X11

    11. XM_054334685.1 → XP_054190660.1  leucine-rich repeat-containing protein 71 isoform X10

    12. XM_054334686.1 → XP_054190661.1  leucine-rich repeat-containing protein 71 isoform X10

    13. XM_054334683.1 → XP_054190658.1  leucine-rich repeat-containing protein 71 isoform X8

    14. XM_054334689.1 → XP_054190664.1  leucine-rich repeat-containing protein 71 isoform X12

    15. XM_054334690.1 → XP_054190665.1  leucine-rich repeat-containing protein 71 isoform X13

    16. XM_054334687.1 → XP_054190662.1  leucine-rich repeat-containing protein 71 isoform X10

    RNA

    1. XR_008485936.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N4P6.1 GenPept UniProtKB/Swiss-Prot:Q8N4P6

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