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    FZD8 frizzled class receptor 8 [ Homo sapiens (human) ]

    Gene ID: 8325, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FZD8provided by HGNC
    Official Full Name
    frizzled class receptor 8provided by HGNC
    Primary source
    HGNC:HGNC:4046
    See related
    Ensembl:ENSG00000177283 MIM:606146; AllianceGenome:HGNC:4046
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FZ-8; hFZ8
    Summary
    This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]
    Orthologs
    mouse all
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    Genomic context

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    See FZD8 in Genome Data Viewer
    Location:
    10p11.21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (35638247..35642296, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (35668401..35672451, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35927175..35931224, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984221 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:35883203-35883845 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:35889926-35890176 Neighboring gene gap junction protein delta 4 Neighboring gene VISTA enhancer hs1588 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:35927732-35928593 Neighboring gene Sharpr-MPRA regulatory region 6098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3269 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2308 Neighboring gene zinc finger protein 469-like Neighboring gene uncharacterized LOC105376494 Neighboring gene microRNA 4683 Neighboring gene uncharacterized LOC124902411 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:35952948-35953138

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular model of the Wnt protein binding site on the surface of dimeric CRD domain of the hFzd8 receptor. Voronkov AE, et al. Dokl Biochem Biophys, 2008 Mar-Apr. PMID 18505162
    2. A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis. Spanjer AI, et al. Thorax, 2016 Apr. PMID 26797711
    3. Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2. Saitoh T, et al. Int J Oncol, 2001 May. PMID 11295046
    4. Wnt receptor Frizzled 8 is a target of ERG in prostate cancer. Chakravarthi BVSK, et al. Prostate, 2018 Dec. PMID 30051493
    5. MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8. Xu L, et al. Oncotarget, 2016 Jun 28. PMID 27276676, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis.
      Title: CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis.
    2. Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.
      Title: Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.
    3. MiR-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting FZD8.
      Title: MiR-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting FZD8.
    4. Frizzled-4 is required for normal bone acquisition despite compensation by Frizzled-8.
      Title: Frizzled-4 is required for normal bone acquisition despite compensation by Frizzled-8.
    5. FZD8 Indicates a Poor Prognosis and Promotes Gastric Cancer Invasion and Metastasis via B-Catenin Signaling Pathway.
      Title: FZD8 Indicates a Poor Prognosis and Promotes Gastric Cancer Invasion and Metastasis via B-Catenin Signaling Pathway.
    6. Expression of FZD8 is directly correlated with ERG expression in prostate cancer. Furthermore, we show that ERG directly targets and activates FZD8 by binding to its promoter. This activation is specific to ETS transcription factor ERG and not ETV1.
      Title: Wnt receptor Frizzled 8 is a target of ERG in prostate cancer.
    7. FZD8 forms a TGF-beta-regulated complex with TGF-beta receptors that is mediated by the extracellular domains of FZD8 and TGFBR1
      Title: Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer.
    8. miR-375 functions as a tumor-suppressive microRNA by directly acting upon FZD8, which may serve as a new therapeutic target to inhibit tumor metastasis in colorectal cancer
      Title: MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8.
    9. Elevated expression of TP53 target FZD8 promoted prostate cancer bone metastasis by activating the canonical Wnt/beta-catenin signaling pathway.
      Title: FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt/β-catenin signaling.
    10. these findings suggest that miR-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/b-catenin signaling pathway and manipulation of miR-100 may provide a promoting therapeutic strategy for cancer breast treatment.
      Title: MicroRNA-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/β-catenin signaling pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    EBI GWAS Catalog
    Genetically distinct subsets within ANCA-associated vasculitis.
    EBI GWAS Catalog
    Genome-wide association study of periodontal pathogen colonization.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Wnt receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Wnt-Frizzled-LRP5/6 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in neuronal dense core vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    frizzled-8
    Names
    frizzled 8, seven transmembrane spanning receptor
    frizzled family receptor 8
    frizzled homolog 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029968.1 RefSeqGene

      Range
      4139..8188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_031866.3 → NP_114072.1  frizzled-8 precursor

      See identical proteins and their annotated locations for NP_114072.1

      Status: REVIEWED

      Source sequence(s)
      AL121749
      Consensus CDS
      CCDS7192.1
      UniProtKB/Swiss-Prot
      Q9H461
      Related
      ENSP00000363826.1, ENST00000374694.3
      Conserved Domains (2) summary
      cd07461
      Location:31 → 155
      CRD_FZ8; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 8 (Fz8) receptor
      cd15250
      Location:267 → 618
      7tmF_FZD8; class F frizzled subfamily 8, member of 7-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      35638247..35642296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      35668401..35672451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H461.1 GenPept UniProtKB/Swiss-Prot:Q9H461

    Gene LinkOut

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