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    Gypc glycophorin C [ Mus musculus (house mouse) ]

    Gene ID: 71683, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gypcprovided by MGI
    Official Full Name
    glycophorin Cprovided by MGI
    Primary source
    MGI:MGI:1098566
    See related
    Ensembl:ENSMUSG00000090523 AllianceGenome:MGI:1098566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd236r; 0610037F22Rik
    Summary
    Located in cortical cytoskeleton and membrane. Is expressed in central nervous system; liver lobe; and pancreas mesenchyme. Human ortholog(s) of this gene implicated in malaria. Orthologous to human GYPC (glycophorin C (Gerbich blood group)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14.5 (RPKM 29.8), liver E14 (RPKM 27.7) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gypc in Genome Data Viewer
    Location:
    18 B1; 18 18.05 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (32661373..32693087, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32528320..32560034, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 20136 Neighboring gene predicted gene 44577 Neighboring gene VISTA enhancer mm291 Neighboring gene STARR-positive B cell enhancer ABC_E4241 Neighboring gene predicted gene, 35480 Neighboring gene predicted gene, 25826

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Stem Cell Strategy Identifies Glycophorin C as a Major Erythrocyte Receptor for the Rodent Malaria Parasite Plasmodium berghei. Yiangou L, et al. PLoS One, 2016. PMID 27362409, Free PMC Article
    2. Cloning and expression of a murine histone deacetylase 3 (mHdac3) cDNA and mapping to a region of conserved synteny between murine chromosome 18 and human chromosome 5. Dangond F, et al. Mol Cell Biol Res Commun, 1999 Aug. PMID 10542131
    3. Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating. Huang YS, et al. Sci Rep, 2017 Jul 12. PMID 28701737, Free PMC Article
    4. Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice. Robledo RF, et al. Blood, 2008 Nov 15. PMID 18723693, Free PMC Article
    5. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in cortical cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycophorin-C
    Names
    Gerbich antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048207.1 → NP_001041672.1  glycophorin-C isoform 1

      See identical proteins and their annotated locations for NP_001041672.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK002769, AY234183
      Consensus CDS
      CCDS57118.1
      UniProtKB/Swiss-Prot
      Q6XFR5, Q78HU7
      Related
      ENSMUSP00000134317.2, ENSMUST00000174459.2
      Conserved Domains (1) summary
      smart00294
      Location:47 → 65
      4.1m; putative band 4.1 homologues' binding motif

    2. NM_001347610.1 → NP_001334539.1  glycophorin-C isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter tha isoform 1.
      Source sequence(s)
      AC098881, AK002769, BB842332, BE951636
      Consensus CDS
      CCDS84368.1
      UniProtKB/TrEMBL
      F7D1I5, G3UXY6
      Related
      ENSMUSP00000133874.2, ENSMUST00000174000.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      32661373..32693087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027863.2: Suppressed sequence

      Description
      NM_027863.2: This RefSeq was permanently suppressed because the coding region was annotated in the wrong location, therefore, representing the wrong protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q78HU7.2 GenPept UniProtKB/Swiss-Prot:Q78HU7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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