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    PWRN1 Prader-Willi region non-protein coding RNA 1 [ Homo sapiens (human) ]

    Gene ID: 791114, updated on 17-Sep-2024

    Summary

    Official Symbol
    PWRN1provided by HGNC
    Official Full Name
    Prader-Willi region non-protein coding RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:33235
    See related
    Ensembl:ENSG00000259905 MIM:611215; AllianceGenome:HGNC:33235
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LOHAN1; NCRNA00198
    Summary
    This gene is located in the Prader-Willi syndrome (PWS) region of chromosome 15, which is known to undergo imprinting. The transcript is believed to be non-coding. It is bi-allelically expressed in testis and kidney, but mono-allelically expressed from the paternal allele in brain. This gene is poly-adenylated and is known to undergo alternative splicing. Transcript variants may represent part of a complex imprinting center-SNURF-SNRPN transcription unit. The contribution of this gene to the PWS phenotype is unknown, but it has been suggested that it may play a role in establishing paternal imprinting in the PWS region, perhaps by maintaining the paternal allele in an open chromatin configuration. [provided by RefSeq, Sep 2009]
    Expression
    Restricted expression toward testis (RPKM 11.5) See more
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    Genomic context

    See PWRN1 in Genome Data Viewer
    Location:
    15q11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (24558157..24587780)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (22292281..22321898)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (24803304..24832927)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370733 Neighboring gene uncharacterized LOC102725165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:24722703-24723202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:24731350-24731850 Neighboring gene Prader-Willi region non-protein coding RNA 3 Neighboring gene NANOG hESC enhancer GRCh37_chr15:24877390-24877896 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:24932126-24932730 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:24942053-24942599 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:24941505-24942052 Neighboring gene H3K27ac hESC enhancers GRCh37_chr15:25017418-25018314 and GRCh37_chr15:25018315-25019210 Neighboring gene nuclear pore associated protein 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25101506-25102019 Neighboring gene Sharpr-MPRA regulatory region 849 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25103559-25104072 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25104073-25104585 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:25107499-25108228 Neighboring gene small nucleolar RNA U13 Neighboring gene small nucleolar RNA host gene 14 Neighboring gene small nuclear ribonucleoprotein polypeptide N

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016177.1 RefSeqGene

      Range
      5001..34624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. NR_026646.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BC034815
      Related
      ENST00000568609.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      24558157..24587780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160017.1 Reference GRCh38.p14 PATCHES

      Range
      5273485..5500427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007069211.1 RNA Sequence

    2. XR_007069210.1 RNA Sequence

    3. XR_007069212.1 RNA Sequence

    4. XR_007069213.1 RNA Sequence

    5. XR_007069215.1 RNA Sequence

    6. XR_007069208.1 RNA Sequence

    7. XR_007069214.1 RNA Sequence

    8. XR_007069216.1 RNA Sequence

    9. XR_007069209.1 RNA Sequence

    10. XR_007069217.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      22292281..22321898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)