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    STK25 serine/threonine kinase 25 [ Homo sapiens (human) ]

    Gene ID: 10494, updated on 14-Nov-2024

    Summary

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    Official Symbol
    STK25provided by HGNC
    Official Full Name
    serine/threonine kinase 25provided by HGNC
    Primary source
    HGNC:HGNC:11404
    See related
    Ensembl:ENSG00000115694 MIM:602255; AllianceGenome:HGNC:11404
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SOK1; YSK1
    Summary
    This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
    Expression
    Ubiquitous expression in brain (RPKM 17.8), thyroid (RPKM 17.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STK25 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (241492670..241509572, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241992007..242008899, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242432085..242448987, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242422458-242422958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242422959-242423459 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242429627-242430140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242430141-242430656 Neighboring gene microRNA 3133 Neighboring gene KCTD5 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242445132-242445668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12540 Neighboring gene uncharacterized LOC107985788 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242460159-242460383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12541 Neighboring gene uncharacterized LOC105373974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242486359-242486892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242490880-242491690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12544 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12545 Neighboring gene BOK antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242509471-242510095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242515160-242515660 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:242518885-242519386 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:242519387-242519886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242523714-242524242 Neighboring gene BCL2 family apoptosis regulator BOK Neighboring gene RNA, 5S ribosomal pseudogene 122 Neighboring gene THAP domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans. Amrutkar M, et al. Diabetologia, 2016 Feb. PMID 26553096
    2. STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer. Wu F, et al. J Exp Clin Cancer Res, 2018 Jul 11. PMID 29996891, Free PMC Article
    3. STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism. Bae SJ, et al. Elife, 2020 Apr 15. PMID 32292165, Free PMC Article
    4. STK25: a viable therapeutic target for cancer treatments? Chen KQ, et al. Anticancer Drugs, 2023 Oct 1. PMID 36728989
    5. SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death. Nogueira E, et al. J Biol Chem, 2008 Jun 6. PMID 18364353, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STK25: a viable therapeutic target for cancer treatments?
      Title: STK25: a viable therapeutic target for cancer treatments?
    2. STK25 inhibits PKA signaling by phosphorylating PRKAR1A.
      Title: STK25 inhibits PKA signaling by phosphorylating PRKAR1A.
    3. Downregulation of STK25 promotes autophagy via the Janus kinase 2/signal transducer and activator of transcription 3 pathway in colorectal cancer.
      Title: Downregulation of STK25 promotes autophagy via the Janus kinase 2/signal transducer and activator of transcription 3 pathway in colorectal cancer.
    4. Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3beta/Nrf2 pathway.
      Title: Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway.
    5. Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways.
      Title: Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways.
    6. Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.
      Title: Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.
    7. STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism.
      Title: STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism.
    8. Our results demonstrated that STK25 negatively regulates the proliferation and glycolysis via GOLPH3-dependent mTOR signaling. Accordingly, STK25 could be a potential therapeutic target for the treatment of CRC.
      Title: STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer.
    9. Loss of STK25 promotes YAP/TAZ activation and enhanced cellular proliferation, even under normally growth-suppressive conditions both in vitro and in vivo.
      Title: Identification of the kinase STK25 as an upstream activator of LATS signaling.
    10. hYSK1 blocks the p21(WAF1/Cip1) functions by direct interaction and inhibits the p16(INK4a) expression and induces MMP-2 expression by its regulations of SP-1 transcriptional activity under the hypoxia conditions.
      Title: p21(WAF1/Cip1) Regulation by hYSK1 Activates SP-1 Transcription Factor and Increases MMP-2 Expression under Hypoxic Conditions.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ43907, DKFZp686J1430

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Golgi reassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of Golgi localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to hydrogen peroxide IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to oxidative stress TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 25
    Names
    Ste20, yeast homolog
    ste20-like kinase
    ste20/oxidant stress response kinase 1
    sterile 20/oxidant stress-response kinase 1
    NP_001258906.1
    NP_001258907.1
    NP_001258908.1
    NP_001258909.1
    NP_001269234.1
    NP_001269235.1
    NP_001269236.1
    NP_001269237.1
    NP_006365.2
    XP_011508795.1
    XP_011508796.1
    XP_011508797.1
    XP_011508798.1
    XP_016858659.1
    XP_047298880.1
    XP_047298881.1
    XP_054196157.1
    XP_054196158.1
    XP_054196159.1
    XP_054196160.1
    XP_054196161.1
    XP_054196162.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271977.2 → NP_001258906.1  serine/threonine-protein kinase 25 isoform 1

      See identical proteins and their annotated locations for NP_001258906.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AC110299, BC007852, BC091505, HY315908
      Consensus CDS
      CCDS2549.1
      UniProtKB/Swiss-Prot
      A8K6Z3, A8K7D2, B7Z9K1, O00506, Q15522, Q5BJF1
      UniProtKB/TrEMBL
      A0A024R4B2, A0A0S2Z4Y9, Q96BA2
      Related
      ENSP00000325748.4, ENST00000316586.9
      Conserved Domains (1) summary
      cd06642
      Location:15 → 291
      STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

    2. NM_001271978.2 → NP_001258907.1  serine/threonine-protein kinase 25 isoform 1

      See identical proteins and their annotated locations for NP_001258907.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AC110299, BC015793, BU541010, HY315908
      Consensus CDS
      CCDS2549.1
      UniProtKB/Swiss-Prot
      A8K6Z3, A8K7D2, B7Z9K1, O00506, Q15522, Q5BJF1
      UniProtKB/TrEMBL
      A0A024R4B2, A0A0S2Z4Y9, Q96BA2
      Related
      ENSP00000385687.1, ENST00000401869.5
      Conserved Domains (1) summary
      cd06642
      Location:15 → 291
      STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

    3. NM_001271979.2 → NP_001258908.1  serine/threonine-protein kinase 25 isoform 2

      See identical proteins and their annotated locations for NP_001258908.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. Variants 8 and 9 encode the same isoform (2).
      Source sequence(s)
      AC110299, AK092161, DC353271, HY315908
      Consensus CDS
      CCDS63200.1
      UniProtKB/TrEMBL
      A0A0S2Z4Y2, B3KRS6
      Related
      ENSP00000384444.3, ENST00000405883.7
      Conserved Domains (1) summary
      cl21453
      Location:12 → 214
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001271980.2 → NP_001258909.1  serine/threonine-protein kinase 25 isoform 2

      See identical proteins and their annotated locations for NP_001258909.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. Variants 8 and 9 encode the same isoform (2).
      Source sequence(s)
      AC110299, AK291808, CB250694, HY315908
      Consensus CDS
      CCDS63200.1
      UniProtKB/TrEMBL
      A0A0S2Z4Y2, B3KRS6
      Related
      ENSP00000385541.1, ENST00000405585.5
      Conserved Domains (1) summary
      cl21453
      Location:12 → 214
      PKc_like; Protein Kinases, catalytic domain

    5. NM_001282305.1 → NP_001269234.1  serine/threonine-protein kinase 25 isoform 3

      See identical proteins and their annotated locations for NP_001269234.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon structure and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2, 6, and 7 encode the same isoform (3).
      Source sequence(s)
      AC110299, AK303719, CB250694, DA624380, HY315908
      Consensus CDS
      CCDS63199.1
      UniProtKB/TrEMBL
      B4E185
      Related
      ENSP00000444886.1, ENST00000543554.5
      Conserved Domains (1) summary
      cl21453
      Location:1 → 197
      PKc_like; Protein Kinases, catalytic domain

    6. NM_001282306.2 → NP_001269235.1  serine/threonine-protein kinase 25 isoform 4

      See identical proteins and their annotated locations for NP_001269235.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (4) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC110299, AK301214, CB250694, DC353271, HY315908
      UniProtKB/TrEMBL
      B4DVS7, B4E185
      Conserved Domains (2) summary
      smart00220
      Location:16 → 196
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:16 → 217
      PKc_like; Protein Kinases, catalytic domain

    7. NM_001282307.2 → NP_001269236.1  serine/threonine-protein kinase 25 isoform 3

      See identical proteins and their annotated locations for NP_001269236.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an exon which contains a portion of the 5' UTR and 5' coding region including the start codon, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2, 6, and 7 encode the same isoform (3).
      Source sequence(s)
      AC110299, AK297374, BC007852, DC353271, HY315908
      Consensus CDS
      CCDS63199.1
      UniProtKB/TrEMBL
      B4E185
      Related
      ENSP00000446008.1, ENST00000535007.5
      Conserved Domains (1) summary
      cl21453
      Location:1 → 197
      PKc_like; Protein Kinases, catalytic domain

    8. NM_001282308.2 → NP_001269237.1  serine/threonine-protein kinase 25 isoform 3

      See identical proteins and their annotated locations for NP_001269237.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an exon which contains a portion of the 5' UTR and 5' coding region including the start codon, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2, 6, and 7 encode the same isoform (3).
      Source sequence(s)
      AC110299, AK315966, CB250694, HY315908
      Consensus CDS
      CCDS63199.1
      UniProtKB/TrEMBL
      B4E185
      Conserved Domains (1) summary
      cl21453
      Location:1 → 197
      PKc_like; Protein Kinases, catalytic domain

    9. NM_006374.5 → NP_006365.2  serine/threonine-protein kinase 25 isoform 1

      See identical proteins and their annotated locations for NP_006365.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AC110299, BC007852, HY315908
      Consensus CDS
      CCDS2549.1
      UniProtKB/Swiss-Prot
      A8K6Z3, A8K7D2, B7Z9K1, O00506, Q15522, Q5BJF1
      UniProtKB/TrEMBL
      A0A024R4B2, A0A0S2Z4Y9, Q96BA2
      Related
      ENSP00000384162.3, ENST00000403346.7
      Conserved Domains (1) summary
      cd06642
      Location:15 → 291
      STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      241492670..241509572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510495.3 → XP_011508797.1  serine/threonine-protein kinase 25 isoform X3

      See identical proteins and their annotated locations for XP_011508797.1

      UniProtKB/TrEMBL
      B4DVS7, B4E185
      Conserved Domains (2) summary
      smart00220
      Location:16 → 196
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:16 → 217
      PKc_like; Protein Kinases, catalytic domain

    2. XM_047442925.1 → XP_047298881.1  serine/threonine-protein kinase 25 isoform X3

      UniProtKB/TrEMBL
      B4DVS7

    3. XM_011510494.3 → XP_011508796.1  serine/threonine-protein kinase 25 isoform X3

      See identical proteins and their annotated locations for XP_011508796.1

      UniProtKB/TrEMBL
      B4DVS7, B4E185
      Conserved Domains (2) summary
      smart00220
      Location:16 → 196
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:16 → 217
      PKc_like; Protein Kinases, catalytic domain

    4. XM_017003170.2 → XP_016858659.1  serine/threonine-protein kinase 25 isoform X3

      UniProtKB/TrEMBL
      B4DVS7, B4E185
      Conserved Domains (2) summary
      smart00220
      Location:16 → 196
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:16 → 217
      PKc_like; Protein Kinases, catalytic domain

    5. XM_047442924.1 → XP_047298880.1  serine/threonine-protein kinase 25 isoform X2

    6. XM_011510496.4 → XP_011508798.1  serine/threonine-protein kinase 25 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:20 → 270
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06642
      Location:15 → 291
      STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

    7. XM_011510493.4 → XP_011508795.1  serine/threonine-protein kinase 25 isoform X1

      UniProtKB/TrEMBL
      Q96BA2
      Conserved Domains (2) summary
      smart00220
      Location:20 → 270
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06642
      Location:15 → 291
      STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      241992007..242008899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340186.1 → XP_054196161.1  serine/threonine-protein kinase 25 isoform X3

      UniProtKB/TrEMBL
      B4DVS7

    2. XM_054340184.1 → XP_054196159.1  serine/threonine-protein kinase 25 isoform X3

      UniProtKB/TrEMBL
      B4DVS7

    3. XM_054340185.1 → XP_054196160.1  serine/threonine-protein kinase 25 isoform X3

      UniProtKB/TrEMBL
      B4DVS7

    4. XM_054340183.1 → XP_054196158.1  serine/threonine-protein kinase 25 isoform X2

    5. XM_054340187.1 → XP_054196162.1  serine/threonine-protein kinase 25 isoform X4

    6. XM_054340182.1 → XP_054196157.1  serine/threonine-protein kinase 25 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00506.1 GenPept UniProtKB/Swiss-Prot:O00506

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