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    YEATS2 YEATS domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 55689, updated on 28-Oct-2024

    Summary

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    Official Symbol
    YEATS2provided by HGNC
    Official Full Name
    YEATS domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:25489
    See related
    Ensembl:ENSG00000163872 MIM:613373; AllianceGenome:HGNC:25489
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAME4
    Summary
    Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]
    Expression
    Ubiquitous expression in ovary (RPKM 7.4), brain (RPKM 7.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See YEATS2 in Genome Data Viewer
    Location:
    3q27.1
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (183697797..183812624)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (186507277..186622124)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183415585..183530412)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374248 Neighboring gene uncharacterized LOC107986162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14946 Neighboring gene kelch like family member 24 Neighboring gene NANOG hESC enhancer GRCh37_chr3:183384502-183385010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14947 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:183527422-183528621 Neighboring gene YEATS2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:183535409-183536020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14950 Neighboring gene MAP6 domain containing 1 Neighboring gene presenilin associated rhomboid like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14951

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. YEATS2 regulates the activation of TAK1/NF-κB pathway and is critical for pancreatic ductal adenocarcinoma cell survival. Sheng H, et al. Cell Biol Toxicol, 2023 Jun. PMID 34686948
    2. YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer. Mi W, et al. Nat Commun, 2017 Oct 20. PMID 29057918, Free PMC Article
    3. TTTCA repeat insertions in an intron of YEATS2 in benign adult familial myoclonic epilepsy type 4. Yeetong P, et al. Brain, 2019 Nov 1. PMID 31539032
    4. YEATS2 is a selective histone crotonylation reader. Zhao D, et al. Cell Res, 2016 May. PMID 27103431, Free PMC Article
    5. YEATS domain-containing 2 (YEATS2), targeted by microRNA miR-378a-5p, regulates growth and metastasis in head and neck squamous cell carcinoma. Sha T, et al. Bioengineered, 2021 Dec. PMID 34587874, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth.
      Title: Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth.
    2. YEATS2 regulates the activation of TAK1/NF-kappaB pathway and is critical for pancreatic ductal adenocarcinoma cell survival.
      Title: YEATS2 regulates the activation of TAK1/NF-κB pathway and is critical for pancreatic ductal adenocarcinoma cell survival.
    3. YEATS domain-containing 2 (YEATS2), targeted by microRNA miR-378a-5p, regulates growth and metastasis in head and neck squamous cell carcinoma.
      Title: YEATS domain-containing 2 (YEATS2), targeted by microRNA miR-378a-5p, regulates growth and metastasis in head and neck squamous cell carcinoma.
    4. YEATS2 is a target of HIF1alpha and promotes pancreatic cancer cell proliferation and migration.
      Title: YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration.
    5. our findings suggest that benign adult familial myoclonic epilepsy type 4 is caused by the insertions of the intronic TTTCA repeats in YEATS2
      Title: TTTCA repeat insertions in an intron of YEATS2 in benign adult familial myoclonic epilepsy type 4.
    6. YEATS2 is a selective histone crotonylation reader.
      Title: YEATS2 is a selective histone crotonylation reader.
    7. YEATS2 gene is highly amplified in human non-small cell lung cancer (NSCLC) and is required for cancer cell growth and survival
      Title: YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Epilepsy, familial adult myoclonic, 4
    MedGen: C3554560 OMIM: 615127 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10201, FLJ12841, FLJ13308, FLJ33401, FLJ34335, KIAA1197

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables TBP-class protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone reader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of tubulin deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tubulin deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of ATAC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    YEATS domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_054747.1 RefSeqGene

      Range
      5001..119828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001351369.2 → NP_001338298.1  YEATS domain-containing protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC068769, AC131160
      Consensus CDS
      CCDS43175.1
      UniProtKB/Swiss-Prot
      A7E2B9, D3DNS9, Q641P6, Q9NW96, Q9ULM3
      Conserved Domains (1) summary
      pfam03366
      Location:231 → 310
      YEATS; YEATS family

    2. NM_001351370.2 → NP_001338299.1  YEATS domain-containing protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC068769, AC131160
      Conserved Domains (1) summary
      pfam03366
      Location:231 → 310
      YEATS; YEATS family

    3. NM_001351371.2 → NP_001338300.1  YEATS domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC068769
      Conserved Domains (1) summary
      pfam03366
      Location:231 → 310
      YEATS; YEATS family

    4. NM_018023.5 → NP_060493.3  YEATS domain-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_060493.3

      Status: REVIEWED

      Source sequence(s)
      AC068769, BC082270, BC150273, CA416892
      Consensus CDS
      CCDS43175.1
      UniProtKB/Swiss-Prot
      A7E2B9, D3DNS9, Q641P6, Q9NW96, Q9ULM3
      Related
      ENSP00000306983.5, ENST00000305135.10
      Conserved Domains (1) summary
      pfam03366
      Location:231 → 310
      YEATS; YEATS family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      183697797..183812624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448527.1 → XP_047304483.1  YEATS domain-containing protein 2 isoform X1

    2. XM_047448528.1 → XP_047304484.1  YEATS domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      A7E2B9, D3DNS9, Q641P6, Q9NW96, Q9ULM3

    3. XM_011512965.2 → XP_011511267.1  YEATS domain-containing protein 2 isoform X4

      Conserved Domains (1) summary
      cl19881
      Location:217 → 256
      YEATS; YEATS family

    4. XM_047448531.1 → XP_047304487.1  YEATS domain-containing protein 2 isoform X5

    5. XM_047448534.1 → XP_047304490.1  YEATS domain-containing protein 2 isoform X6

    6. XM_047448535.1 → XP_047304491.1  YEATS domain-containing protein 2 isoform X7

    7. XM_011512966.2 → XP_011511268.1  YEATS domain-containing protein 2 isoform X8

      Conserved Domains (1) summary
      pfam03366
      Location:231 → 310
      YEATS; YEATS family

    8. XM_047448542.1 → XP_047304498.1  YEATS domain-containing protein 2 isoform X11

    9. XM_005247598.6 → XP_005247655.1  YEATS domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005247655.1

      Conserved Domains (1) summary
      pfam03366
      Location:231 → 310
      YEATS; YEATS family

    10. XM_017006810.2 → XP_016862299.1  YEATS domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      A7E2B9, D3DNS9, Q641P6, Q9NW96, Q9ULM3
      Conserved Domains (1) summary
      pfam03366
      Location:231 → 310
      YEATS; YEATS family

    11. XM_047448530.1 → XP_047304486.1  YEATS domain-containing protein 2 isoform X4

    12. XM_047448532.1 → XP_047304488.1  YEATS domain-containing protein 2 isoform X5

    13. XM_047448536.1 → XP_047304492.1  YEATS domain-containing protein 2 isoform X8

    14. XM_047448538.1 → XP_047304494.1  YEATS domain-containing protein 2 isoform X9

    15. XM_047448533.1 → XP_047304489.1  YEATS domain-containing protein 2 isoform X5

    16. XM_047448537.1 → XP_047304493.1  YEATS domain-containing protein 2 isoform X8

    17. XM_047448540.1 → XP_047304496.1  YEATS domain-containing protein 2 isoform X9

    18. XM_017006811.3 → XP_016862300.1  YEATS domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      pfam03366
      Location:178 → 257
      YEATS; YEATS family

    19. XM_047448541.1 → XP_047304497.1  YEATS domain-containing protein 2 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      186507277..186622124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347198.1 → XP_054203173.1  YEATS domain-containing protein 2 isoform X1

    2. XM_054347200.1 → XP_054203175.1  YEATS domain-containing protein 2 isoform X2

    3. XM_054347202.1 → XP_054203177.1  YEATS domain-containing protein 2 isoform X4

    4. XM_054347204.1 → XP_054203179.1  YEATS domain-containing protein 2 isoform X5

    5. XM_054347207.1 → XP_054203182.1  YEATS domain-containing protein 2 isoform X6

    6. XM_054347208.1 → XP_054203183.1  YEATS domain-containing protein 2 isoform X7

    7. XM_054347209.1 → XP_054203184.1  YEATS domain-containing protein 2 isoform X8

    8. XM_054347215.1 → XP_054203190.1  YEATS domain-containing protein 2 isoform X11

    9. XM_054347197.1 → XP_054203172.1  YEATS domain-containing protein 2 isoform X1

    10. XM_054347199.1 → XP_054203174.1  YEATS domain-containing protein 2 isoform X2

    11. XM_054347212.1 → XP_054203187.1  YEATS domain-containing protein 2 isoform X9

    12. XM_054347210.1 → XP_054203185.1  YEATS domain-containing protein 2 isoform X8

    13. XM_054347203.1 → XP_054203178.1  YEATS domain-containing protein 2 isoform X4

    14. XM_054347205.1 → XP_054203180.1  YEATS domain-containing protein 2 isoform X5

    15. XM_054347206.1 → XP_054203181.1  YEATS domain-containing protein 2 isoform X5

    16. XM_054347211.1 → XP_054203186.1  YEATS domain-containing protein 2 isoform X8

    17. XM_054347213.1 → XP_054203188.1  YEATS domain-containing protein 2 isoform X9

    18. XM_054347201.1 → XP_054203176.1  YEATS domain-containing protein 2 isoform X3

    19. XM_054347214.1 → XP_054203189.1  YEATS domain-containing protein 2 isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULM3.2 GenPept UniProtKB/Swiss-Prot:Q9ULM3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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