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    BCORL1 BCL6 corepressor like 1 [ Homo sapiens (human) ]

    Gene ID: 63035, updated on 14-Nov-2024

    Summary

    Official Symbol
    BCORL1provided by HGNC
    Official Full Name
    BCL6 corepressor like 1provided by HGNC
    Primary source
    HGNC:HGNC:25657
    See related
    Ensembl:ENSG00000085185 MIM:300688; AllianceGenome:HGNC:25657
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SHUVER; BCoR-L1; CXorf10
    Summary
    The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
    Expression
    Broad expression in placenta (RPKM 4.2), testis (RPKM 3.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BCORL1 in Genome Data Viewer
    Location:
    Xq26.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (129980313..130058071)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (128299075..128376871)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (129114955..129192046)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene spalt like transcription factor 4 pseudogene 2 Neighboring gene uncharacterized LOC105373335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20981 Neighboring gene UTP14A small subunit processome component Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129086824-129087554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129093062-129093562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20985 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:129117440-129117676 Neighboring gene uncharacterized LOC124905216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129159157-129159656 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20986 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20988 Neighboring gene Sharpr-MPRA regulatory region 15346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20989 Neighboring gene E74 like ETS transcription factor 4 Neighboring gene Sharpr-MPRA regulatory region 9263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20995 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:129255011-129255220 Neighboring gene RAB33A, member RAS oncogene family Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:129280263-129281462 Neighboring gene apoptosis inducing factor mitochondria associated 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29939

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Shukla-Vernon syndrome
    MedGen: C5193146 OMIM: 301029 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Genome-wide association study of chronic periodontitis in a general German population.
    EBI GWAS Catalog
    GWAS of dental caries patterns in the permanent dentition.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11362, FLJ11632

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    BCL-6 corepressor-like protein 1
    Names
    BCoR-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021274.1 RefSeqGene

      Range
      27496..80390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_628

    mRNA and Protein(s)

    1. NM_001184772.3 → NP_001171701.1  BCL-6 corepressor-like protein 1 isoform 1a

      See identical proteins and their annotated locations for NP_001171701.1

      Status: REVIEWED

      Source sequence(s)
      AL034405, AL136450, KF459400, Z82208
      Consensus CDS
      CCDS94663.1
      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
      Conserved Domains (4) summary
      PHA03247
      Location:198 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1666 → 1779
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1496 → 1527
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1500 → 1591
      Ank_2; Ankyrin repeats (3 copies)
    2. NM_001379450.1 → NP_001366379.1  BCL-6 corepressor-like protein 1 isoform 1a

      Status: REVIEWED

      Source sequence(s)
      AL034405, AL136450, KF459400, Z82208
      Consensus CDS
      CCDS94663.1
      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
      Conserved Domains (4) summary
      PHA03247
      Location:198 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1666 → 1779
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1496 → 1527
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1500 → 1591
      Ank_2; Ankyrin repeats (3 copies)
    3. NM_001379451.1 → NP_001366380.1  BCL-6 corepressor-like protein 1 isoform 1a

      Status: REVIEWED

      Source sequence(s)
      AL034405, AL136450, KF459400, Z82208
      Consensus CDS
      CCDS94663.1
      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
      Related
      ENSP00000437775.2, ENST00000540052.6
      Conserved Domains (4) summary
      PHA03247
      Location:198 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1666 → 1779
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1496 → 1527
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1500 → 1591
      Ank_2; Ankyrin repeats (3 copies)
    4. NM_021946.5 → NP_068765.3  BCL-6 corepressor-like protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL034405, AL136450, KF459400, Z82208
      Consensus CDS
      CCDS14616.1
      UniProtKB/Swiss-Prot
      Q5H9F3
      Related
      ENSP00000218147.7, ENST00000218147.11
      Conserved Domains (4) summary
      cd00204
      Location:1426 → 1530
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14260
      Location:1592 → 1705
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      pfam12796
      Location:1426 → 1517
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:1455 → 1486
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      129980313..130058071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262453.5 → XP_005262510.2  BCL-6 corepressor-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005262510.2

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
      Conserved Domains (4) summary
      PHA03247
      Location:198 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1666 → 1779
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1496 → 1527
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1500 → 1591
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_006724777.4 → XP_006724840.1  BCL-6 corepressor-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006724840.1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
      Conserved Domains (4) summary
      PHA03247
      Location:198 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1666 → 1779
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1496 → 1527
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1500 → 1591
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_047442344.1 → XP_047298300.1  BCL-6 corepressor-like protein 1 isoform X2

    4. XM_017029721.2 → XP_016885210.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
      Conserved Domains (4) summary
      PHA03247
      Location:198 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1666 → 1779
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1496 → 1527
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1500 → 1591
      Ank_2; Ankyrin repeats (3 copies)
    5. XM_047442341.1 → XP_047298297.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    6. XM_047442340.1 → XP_047298296.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    7. XM_005262456.5 → XP_005262513.2  BCL-6 corepressor-like protein 1 isoform X2

      Conserved Domains (5) summary
      cd00204
      Location:1360 → 1474
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14260
      Location:1536 → 1649
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      pfam12796
      Location:1370 → 1461
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1184 → 1297
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1366 → 1397
      ANK; ANK repeat [structural motif]
    8. XM_047442345.1 → XP_047298301.1  BCL-6 corepressor-like protein 1 isoform X2

    9. XM_006724776.4 → XP_006724839.1  BCL-6 corepressor-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006724839.1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
      Conserved Domains (4) summary
      PHA03247
      Location:198 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1666 → 1779
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1496 → 1527
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1500 → 1591
      Ank_2; Ankyrin repeats (3 copies)
    10. XM_047442343.1 → XP_047298299.1  BCL-6 corepressor-like protein 1 isoform X2

    11. XM_047442342.1 → XP_047298298.1  BCL-6 corepressor-like protein 1 isoform X2

    12. XM_005262455.5 → XP_005262512.2  BCL-6 corepressor-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005262512.2

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
      Conserved Domains (4) summary
      PHA03247
      Location:198 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1666 → 1779
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1496 → 1527
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1500 → 1591
      Ank_2; Ankyrin repeats (3 copies)
    13. XM_047442339.1 → XP_047298295.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    14. XM_017029722.2 → XP_016885211.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
      Conserved Domains (4) summary
      PHA03247
      Location:198 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1666 → 1779
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1496 → 1527
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1500 → 1591
      Ank_2; Ankyrin repeats (3 copies)
    15. XM_047442347.1 → XP_047298303.1  BCL-6 corepressor-like protein 1 isoform X4

    16. XM_047442346.1 → XP_047298302.1  BCL-6 corepressor-like protein 1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      128299075..128376871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327551.1 → XP_054183526.1  BCL-6 corepressor-like protein 1 isoform X2

    2. XM_054327544.1 → XP_054183519.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    3. XM_054327548.1 → XP_054183523.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    4. XM_054327553.1 → XP_054183528.1  BCL-6 corepressor-like protein 1 isoform X2

    5. XM_054327543.1 → XP_054183518.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    6. XM_054327545.1 → XP_054183520.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    7. XM_054327542.1 → XP_054183517.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    8. XM_054327549.1 → XP_054183524.1  BCL-6 corepressor-like protein 1 isoform X2

    9. XM_054327546.1 → XP_054183521.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    10. XM_054327552.1 → XP_054183527.1  BCL-6 corepressor-like protein 1 isoform X2

    11. XM_054327550.1 → XP_054183525.1  BCL-6 corepressor-like protein 1 isoform X2

    12. XM_054327540.1 → XP_054183515.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    13. XM_054327541.1 → XP_054183516.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    14. XM_054327547.1 → XP_054183522.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    15. XM_054327555.1 → XP_054183530.1  BCL-6 corepressor-like protein 1 isoform X4

    16. XM_054327554.1 → XP_054183529.1  BCL-6 corepressor-like protein 1 isoform X3