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    ZNF736 zinc finger protein 736 [ Homo sapiens (human) ]

    Gene ID: 728927, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZNF736provided by HGNC
    Official Full Name
    zinc finger protein 736provided by HGNC
    Primary source
    HGNC:HGNC:32467
    See related
    Ensembl:ENSG00000234444 AllianceGenome:HGNC:32467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in testis (RPKM 3.1), bone marrow (RPKM 2.4) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF736 in Genome Data Viewer
    Location:
    7q11.21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (64313961..64356634)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (65521810..65564509)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (63774339..63817012)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375323 Neighboring gene uncharacterized LOC105375322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26057 Neighboring gene MPRA-validated peak6529 silencer Neighboring gene tripartite motif containing 60 pseudogene 18 Neighboring gene uncharacterized LOC105375321 Neighboring gene uncharacterized LOC105375324

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    2. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article
    3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ43489, FLJ44406, DKFZp781H0161

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 736
    Names
    KRAB-containing zinc-finger repressor protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170905.3 → NP_001164376.1  zinc finger protein 736 isoform 1

      See identical proteins and their annotated locations for NP_001164376.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1), which contains the zinc finger domains.
      Source sequence(s)
      AC073270, AK301806, DB048979
      Consensus CDS
      CCDS55114.1
      UniProtKB/Swiss-Prot
      B4DX44
      Related
      ENSP00000400852.1, ENST00000423484.3
      Conserved Domains (4) summary
      smart00349
      Location:4 → 63
      KRAB; krueppel associated box
      COG5048
      Location:227 → 383
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:383 → 405
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001294255.2 → NP_001281184.1  zinc finger protein 736 isoform 2

      See identical proteins and their annotated locations for NP_001281184.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and its transcription extends past a splice junction used in variant 1, resulting in a different 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC073270, BC031335, DB048979
      Related
      ENST00000488621.1
      Conserved Domains (2) summary
      smart00349
      Location:4 → 63
      KRAB; krueppel associated box
      pfam01352
      Location:4 → 43
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      64313961..64356634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      65521810..65564509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B4DX44.2 GenPept UniProtKB/Swiss-Prot:B4DX44

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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