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    rab-3 Ras-related protein Rab-3 [ Caenorhabditis elegans ]

    Gene ID: 173971, updated on 19-Jun-2024

    Summary

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    Gene symbol
    rab-3
    Gene description
    Ras-related protein Rab-3
    Locus tag
    CELE_C18A3.6
    See related
    AllianceGenome:WB:WBGene00004267
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activity. Involved in several processes, including cholinergic synaptic transmission; positive regulation of anterior/posterior axon guidance; and ventral cord development. Located in neuron projection and synaptic vesicle. Is expressed in nervous system and uv1. Used to study alcohol use disorder and epilepsy. Orthologous to several human genes including RAB3A (RAB3A, member RAS oncogene family) and RAB3B (RAB3B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See rab-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (5721767..5727853, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative rRNA-processing protein EBP2 homolog Neighboring gene ncRNA Neighboring gene Zinc/iron permease Neighboring gene DNA N6-methyl methyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Der GTPase-activating protein YihI

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synaptogenesis Is Modulated by Heparan Sulfate in Caenorhabditis elegans. Lázaro-Peña MI, et al. Genetics, 2018 May. PMID 29559501, Free PMC Article
    2. The C-terminal binding protein (CTBP-1) regulates dorsal SMD axonal morphology in Caenorhabditis elegans. Reid A, et al. Neuroscience, 2015 Dec 17. PMID 26480814
    3. VPS35 and EIF4G1 interactions and novel candidate genes for PD: from genes to pathways and back. Erro R. Mov Disord, 2015 Apr. PMID 25771811
    4. Rab-3 and unc-18 interactions in alcohol sensitivity are distinct from synaptic transmission. Johnson JR, et al. PLoS One, 2013. PMID 24244732, Free PMC Article
    5. A dominant mutation in mec-7/β-tubulin affects axon development and regeneration in Caenorhabditis elegans neurons. Kirszenblat L, et al. Mol Biol Cell, 2013 Feb. PMID 23223572, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our data suggest that AEX-3 activates RAB-3 in the context of AVG axon navigation.
      Title: Pioneer Axon Navigation Is Controlled by AEX-3, a Guanine Nucleotide Exchange Factor for RAB-3 in Caenorhabditis elegans.
    2. Data show that without synaptotagmin 1, the tight coupling between vesicle exocytosis and Rab3 GTP-binding protein membrane disassociation is disrupted.
      Title: Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle.
    3. rep-1 does not functions in the RAB-3 pathway, for synaptic transmission at neuromuscular junctions
      Title: Caenorhabditis elegans Rab escort protein (REP-1) differently regulates each Rab protein function and localization in a tissue-dependent manner.
    4. These data suggest a conserved role of RAB-3-/RAB3A-regulated neurotransmitter release in ethanol-related behaviors.
      Title: Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol.
    5. Vesicles targeted to the presynaptic density by RAB-3/UNC-10 interactions are ideally positioned for efficient calcium-dependent release.
      Title: Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables myosin V binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of anterior/posterior axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of anterior/posterior axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ventral cord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ras-related protein Rab-3
    NP_001021973.1
    • Confirmed by transcript evidence
    NP_001367527.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5721767..5727853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026802.4 → NP_001021973.1  Ras-related protein Rab-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7F488, Q95QV3
      Conserved Domains (2) summary
      smart00175
      Location:37 → 197
      RAB; Rab subfamily of small GTPases
      cd01865
      Location:36 → 200
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

    2. NM_001381435.3 → NP_001367527.1  Ras-related protein Rab-3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94986
      UniProtKB/TrEMBL
      I7F488
      Conserved Domains (1) summary
      cd01865
      Location:22 → 186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94986.1

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