ptl-1 Microtubule-associated protein [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Gene symbol: ptl-1
Gene description: Microtubule-associated protein
Locus tag: CELE_F42G9.9
See related: AllianceGenome:WB:WBGene00004212
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables kinesin binding activity and microtubule binding activity. Involved in microtubule polymerization and positive regulation of nematode male tail tip morphogenesis. Located in axon. Is expressed in several structures, including intestine; nerve ring; neurons; pharynx; and vulval muscle. Used to study amyotrophic lateral sclerosis and tauopathy. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to several human genes including MAPT (microtubule associated protein tau). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ptl-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (765184..771391)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTL-1 functions via neurons to modulate SKN-1, clarifying the role of this protein in the stress response and longevity.
Title: Neuronal protein with tau-like repeats (PTL-1) regulates intestinal SKN-1 nuclear accumulation in response to oxidative stress.
The authors conclude that the spectrin and microtubule cytoskeletons work in combination to protect axons and dendrites from mechanical stress and propose that defects in beta-spectrin and tau may sensitize neurons to damage.
Title: Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling.
The molecular architecture of PTL-1 was proved to be analogous to its mammalian counterparts, MAP2, MAP4, and tau, strongly supporting their evolutionary relationships.
Title: A nematode microtubule-associated protein, PTL-1, closely resembles its mammalian counterparts in overall molecular architecture.
PTL-1 is important for the maintenance of neuronal health as animals age, as well as in the regulation of whole organism lifespan.
Title: PTL-1 regulates neuronal integrity and lifespan in C. elegans.
PTL-1 affects retrograde axonal transport of uncoordinated (UNC)-104 protein in Caenorhabditis elegans.
Title: Tau/PTL-1 associates with kinesin-3 KIF1A/UNC-104 and affects the motor's motility characteristics in C. elegans neurons.
PTL-1 is involved in mechanosensation as well as some aspect of embryogenesis.
Title: The invertebrate microtubule-associated protein PTL-1 functions in mechanosensation and development in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F42G9.9 (e-PCR)
- UniSTS:310295

F42G9.3 (e-PCR)
- UniSTS:319341

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Microtubule-associated protein

NP_001022576.1

Confirmed by transcript evidence

NP_001367353.1

Confirmed by transcript evidence

NP_001367354.1

Confirmed by transcript evidence

NP_001379577.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

765184..771391

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381708.2 → NP_001367354.1 Microtubule-associated protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

P90973, Q17365

Conserved Domains (2) summary

pfam00418
Location:367 → 396

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

pfam03999
Location:176 → 269

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
NM_001381707.2 → NP_001367353.1 Microtubule-associated protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q17365, Q95QG4

Conserved Domains (2) summary

pfam00418
Location:367 → 396

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

pfam03999
Location:176 → 269

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
NM_001027405.7 → NP_001022576.1 Microtubule-associated protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022576.1

Status: REVIEWED

UniProtKB/TrEMBL

O02592, Q17364

Conserved Domains (1) summary

pfam00418
Location:397 → 425

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
NM_001393262.1 → NP_001379577.1 Microtubule-associated protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2KY94

Conserved Domains (2) summary

pfam00418
Location:219 → 248

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

pfam03999
Location:28 → 121

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)