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    damt-1 DNA N6-methyl methyltransferase [ Caenorhabditis elegans ]

    Gene ID: 173970, updated on 2-Nov-2024

    Summary

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    Official Symbol
    damt-1
    Official Full Name
    DNA N6-methyl methyltransferase
    Primary source
    WormBase:WBGene00015939
    Locus tag
    CELE_C18A3.1
    See related
    AllianceGenome:WB:WBGene00015939
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables site-specific DNA-methyltransferase (adenine-specific) activity. Involved in epigenetic regulation of gene expression. Predicted to be active in nucleus. Orthologous to human METTL4 (methyltransferase 4, N6-adenosine). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See damt-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (5720148..5721791)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative rRNA-processing protein EBP2 homolog Neighboring gene ncRNA Neighboring gene Zinc/iron permease Neighboring gene Ras-related protein Rab-3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Beta class amino methyltransferases from bacteria to humans: evolution and structural consequences. Woodcock CB, et al. Nucleic Acids Res, 2020 Oct 9. PMID 32453412, Free PMC Article
    2. DNA Methylation on N6-Adenine in C. elegans. Greer EL, et al. Cell, 2015 May 7. PMID 25936839, Free PMC Article
    3. N(6)-methyldeoxyadenine and histone methylation mediate transgenerational survival advantages induced by hormetic heat stress. Wan QL, et al. Sci Adv, 2021 Jan. PMID 33523838, Free PMC Article
    4. DNA methylation 6 mA and histone methylation involved in multi-/trans-generational reproductive effects in Caenorhabditis elegans induced by Atrazine. Yin J, et al. Ecotoxicol Environ Saf, 2023 Jan 1. PMID 36508798
    5. N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance. Liberman N, et al. Sci Adv, 2020 Apr. PMID 32494643, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity, acting on a nucleic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables site-specific DNA-methyltransferase (adenine-specific) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables site-specific DNA-methyltransferase (adenine-specific) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA N6-methyl methyltransferase
    NP_495127.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5720148..5721791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062726.3 → NP_495127.1  DNA N6-methyl methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495127.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09956
      Conserved Domains (1) summary
      cl01947
      Location:185 → 349
      MT-A70; MT-A70
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09956.1

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