aqp-8 Aquaporin-9 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: aqp-8
Gene description: Aquaporin-9
Locus tag: CELE_K02G10.7
See related: AllianceGenome:WB:WBGene00000176
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glycerol channel activity and water channel activity. Predicted to be involved in glycerol transport and water transport. Located in cell surface. Is expressed in several structures, including coelomocyte; excretory system; germ line; intestinal cell; and non-striated muscle. Human ortholog(s) of this gene implicated in kidney disease. Orthologous to human AQP3 (aquaporin 3 (Gill blood group)) and AQP9 (aquaporin 9). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See aqp-8 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (4702167..4704970, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Propose that the ERM-1/AQP-8 interaction propels lumen extension by translumenal flux, suggesting a direct morphogenetic effect of water-channel-regulated fluid pressure.
Title: Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux.
AQP-8 is a Caenorhabditis elegans aquaporin exclusively expressed in the excretory system, by the POU homeobox transcription factor CEH-6
Title: Transcriptional regulation of AQP-8, a Caenorhabditis elegans aquaporin exclusively expressed in the excretory system, by the POU homeobox transcription factor CEH-6.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K02G10.7 (e-PCR)
- UniSTS:318302

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables channel activity	IEA Inferred from Electronic Annotation more info
enables glycerol channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in glycerol transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in polyol transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Aquaporin-9

NP_001024758.1

Confirmed by transcript evidence

NP_001348812.1

Confirmed by transcript evidence

NP_001348813.1

Confirmed by transcript evidence

NP_001359963.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4702167..4704970 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373283.3 → NP_001359963.1 Aquaporin-9 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q7Z138

Conserved Domains (1) summary

cl00200
Location:21 → 261

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_001361799.3 → NP_001348813.1 Aquaporin-9 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2K5AU16

Conserved Domains (1) summary

cl00200
Location:1 → 96

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_001361800.3 → NP_001348812.1 Aquaporin-9 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2K5AU20
NM_001029587.3 → NP_001024758.1 Aquaporin-9 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024758.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7Z137

Conserved Domains (1) summary

cl00200
Location:21 → 261

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...