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    Tmem150b transmembrane protein 150B [ Mus musculus (house mouse) ]

    Gene ID: 330460, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem150bprovided by MGI
    Official Full Name
    transmembrane protein 150Bprovided by MGI
    Primary source
    MGI:MGI:2679718
    See related
    Ensembl:ENSMUSG00000046456 AllianceGenome:MGI:2679718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem224; A630041N19
    Summary
    Predicted to be involved in autophagy. Predicted to be located in autophagosome membrane and endosome membrane. Predicted to be active in plasma membrane. Orthologous to human TMEM150B (transmembrane protein 150B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 24.1), frontal lobe adult (RPKM 20.5) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem150b in Genome Data Viewer
    Location:
    7 A1; 7 2.72 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4709831..4728250, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4706832..4725251, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6, regulatory subunit 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4605526-4605679 Neighboring gene STARR-positive B cell enhancer ABC_E3695 Neighboring gene HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 Neighboring gene STARR-positive B cell enhancer ABC_E2219 Neighboring gene BR serine/threonine kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E127 Neighboring gene predicted gene, 24537 Neighboring gene predicted gene, 42369

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TMEM150B is dispensable for oocyte maturation and female fertility in mouse. Liu R, et al. Sci Rep, 2020 Dec 7. PMID 33288838, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM150B is dispensable for oocyte maturation and female fertility in mouse.
      Title: TMEM150B is dispensable for oocyte maturation and female fertility in mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31268

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    modulator of macroautophagy TMEM150B
    Names
    transmembrane protein 224

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142792.1 → NP_001136264.1  modulator of macroautophagy TMEM150B isoform 1

      See identical proteins and their annotated locations for NP_001136264.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC161197
      Consensus CDS
      CCDS51975.1
      UniProtKB/Swiss-Prot
      Q8C9L9, Q8R218
      Related
      ENSMUSP00000083549.5, ENSMUST00000086363.5
      Conserved Domains (1) summary
      pfam10277
      Location:4 → 205
      Frag1; Frag1/DRAM/Sfk1 family

    2. NM_177887.4 → NP_808555.1  modulator of macroautophagy TMEM150B isoform 2

      See identical proteins and their annotated locations for NP_808555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 3' sequence, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC161197
      Consensus CDS
      CCDS20742.1
      UniProtKB/Swiss-Prot
      Q8R218
      Related
      ENSMUSP00000083550.5, ENSMUST00000086364.11
      Conserved Domains (1) summary
      pfam10277
      Location:4 → 108
      Frag1; Frag1/DRAM/Sfk1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4709831..4728250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R218.1 GenPept UniProtKB/Swiss-Prot:Q8R218

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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