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    Mblac1 metallo-beta-lactamase domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304346, updated on 2-Nov-2024

    Summary

    Official Symbol
    Mblac1provided by RGD
    Official Full Name
    metallo-beta-lactamase domain containing 1provided by RGD
    Primary source
    RGD:1306932
    See related
    EnsemblRapid:ENSRNOG00000082402 AllianceGenome:RGD:1306932
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306932
    Summary
    Predicted to enable RNA endonuclease activity and metal ion binding activity. Predicted to be involved in histone mRNA metabolic process; mRNA 3'-end processing; and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasm and nucleus. Orthologous to human MBLAC1 (metallo-beta-lactamase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See Mblac1 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (22185142..22186404)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (17071465..17072736)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (19335841..19337103)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 4 subunit mu 1 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene canopy FGF signaling regulator 4 Neighboring gene neurexophilin and PC-esterase domain family, member 5 Neighboring gene neurexophilin and PC-esterase domain family, member 5 like 2

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA endonuclease activity  
    enables RNA endonuclease activity  
    enables metal ion binding  
    enables metal ion binding  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    metallo-beta-lactamase domain-containing protein 1
    Names
    endoribonuclease MBLAC1
    NP_001020167.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024996.1NP_001020167.1  metallo-beta-lactamase domain-containing protein 1

      See identical proteins and their annotated locations for NP_001020167.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079097
      UniProtKB/Swiss-Prot
      Q6AYD1
      UniProtKB/TrEMBL
      A6KST6
      Related
      ENSRNOP00000106336.1, ENSRNOT00000129882.1
      Conserved Domains (2) summary
      COG0491
      Location:81244
      GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
      cd07711
      Location:24240
      MBLAC1-like_MBL-fold; uncharacterized human metallo-beta-lactamase domain-containing protein 1 and related proteins; MBL-fold metallo hydrolase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      22185142..22186404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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