MYH16 myosin heavy chain 16 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MYH16provided by HGNC
Official Full Name: myosin heavy chain 16provided by HGNC
Primary source: HGNC:HGNC:31038
See related: Ensembl:ENSG00000002079 MIM:608580; AllianceGenome:HGNC:31038
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MYH5; MHC20; MYH16P
Summary: The protein coding status of the MYH16 gene is uncertain. In nonhuman primates, this gene encodes a sarcomeric myosin heavy chain expressed in masticatory muscles, but has been hypothesized to be inactivated in humans. Stedman et al. (2004) [PubMed 15042088] suggest that the decrement in masticatory muscle size caused by the inactivation of MYH16 removed an evolutionary constraint on encephalization in early man. However, there is peptide support suggesting that a shorter protein containing only a myosin tail domain is expressed in human. [provided by RefSeq, Jul 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 7q22.1

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (99238829..99311128)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (100477712..100550022)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (98836452..98908751)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MYH16 upregulation is associated with lung adenocarcinoma aggressiveness and immune infiltration.
Title: MYH16 upregulation is associated with lung adenocarcinoma aggressiveness and immune infiltration.
first proteomic distinction between humans and chimpanzees that can be correlated with a traceable anatomic imprint in the fossil record
Title: Myosin gene mutation correlates with anatomical changes in the human lineage.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S1463 (e-PCR)
- UniSTS:69713

RH70329 (e-PCR)
- UniSTS:73839

D7S1553 (e-PCR)
- UniSTS:20630

GDB:1234280 (e-PCR)
- UniSTS:58843

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in anatomical structure formation involved in morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cellular component assembly	IEA Inferred from Electronic Annotation more info
involved_in supramolecular fiber organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of myosin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative uncharacterized protein MYH16

Names: myosin heavy chain 16 (pseudogene); myosin heavy polypeptide 5; myosin, heavy polypeptide 16; sarcomeric myosin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.