FTH1P3 ferritin heavy chain 1 pseudogene 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FTH1P3provided by HGNC
Official Full Name: ferritin heavy chain 1 pseudogene 3provided by HGNC
Primary source: HGNC:HGNC:3990
See related: AllianceGenome:HGNC:3990
Gene type: pseudo
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FTHL3; FTHL3P
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Genomic context

Location:: 2p23.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (27392623..27393576, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (27435022..27435975, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (27615490..27616443, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNAI2/FTH1P3/miR-218-5p Positive Feedback Loop Promotes Colorectal Cancer Metastasis.
Title: SNAI2/FTH1P3/miR-218-5p Positive Feedback Loop Promotes Colorectal Cancer Metastasis.
E2F1-Induced FTH1P3 Promoted Cell Viability and Glycolysis Through miR-377-3p/LDHA Axis in Laryngeal Squamous Cell Carcinoma.
Title: E2F1-Induced FTH1P3 Promoted Cell Viability and Glycolysis Through miR-377-3p/LDHA Axis in Laryngeal Squamous Cell Carcinoma.
E2F1-induced ferritin heavy chain 1 pseudogene 3 (FTH1P3) accelerates non-small cell lung cancer gefitinib resistance.
Title: E2F1-induced ferritin heavy chain 1 pseudogene 3 (FTH1P3) accelerates non-small cell lung cancer gefitinib resistance.
these results suggested that increased expression of FTH1P3 predicts a poor prognosis and promotes aggressive phenotypes of Laryngeal squamous cell cancer (LSCC) by regulating cell proliferation, migration, invasion, apoptosis, and cell cycle, indicating FTH1P3 may serve as a promising therapeutic biomarker for the treatment of LSCC.
Title: Increased expression of lncRNA FTH1P3 predicts a poor prognosis and promotes aggressive phenotypes of laryngeal squamous cell carcinoma.
Study revealed that FTH1P3 was highly expressed in malignant cervical cancer tissues and cell lines. Its downregulation significantly inhibited cell proliferation, invasion and migration, and promoted apoptosis in cervical cancer cells. Results demonstrated that lncRNA FTH1P3 functioned as a promoting factor in cervical cancer by targeting miR145.
Title: The long noncoding RNA FTH1P3 promotes the proliferation and metastasis of cervical cancer through microRNA‑145.
Increased expression of lncRNA FTH1P3 in oral squamous cell carcinoma cells promotes cell migration and invasion by enhancing PI3K/Akt/GSK3b/ Wnt/beta-catenin signaling pathways
Title: Increased expression of lncRNA FTH1P3 promotes oral squamous cell carcinoma cells migration and invasion by enhancing PI3K/Akt/GSK3b/ Wnt/β-catenin signaling.
The results reveal the potential regulatory mechanism of FTH1P3 on breast cancer paclitaxel resistance through miR-206/ABCB1 axis.
Title: Long non-coding RNA FTH1P3 activates paclitaxel resistance in breast cancer through miR-206/ABCB1.
upregulation of FTH1P3 may promote glioma cell proliferation and inhibit apoptosis via regulation of the miR-224-5p/TPD52 axis. FTH1P3 may provide a novel perspective on the pathogenesis of glioma.
Title: Long non‑coding RNA ferritin heavy polypeptide 1 pseudogene 3 controls glioma cell proliferation and apoptosis via regulation of the microRNA‑224‑5p/tumor protein D52 axis.
report that FTH1P3, another intronless pseudogene, is transcribed. FTH1P3 transcript was detected in several cell lines and tissues, suggesting that its transcription is ubiquitary, as it happens for the parental ferritin H gene
Title: FTH1P3, a Novel H-Ferritin Pseudogene Transcriptionally Active, Is Ubiquitously Expressed and Regulated during Cell Differentiation.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S2060E (e-PCR)
- UniSTS:151601

RH94403 (e-PCR)
- UniSTS:119651

MARC_4179-4180:991938416:1 (e-PCR)
- UniSTS:231076

Other Names

ferritin, heavy polypeptide 1 pseudogene 3
ferritin, heavy polypeptide-like 3 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.