Lrpprc leucine-rich pentatricopeptide repeat containing [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrpprcprovided by RGD
Official Full Name: leucine-rich pentatricopeptide repeat containingprovided by RGD
Primary source: RGD:1306575
See related: EnsemblRapid:ENSRNOG00000005877 AllianceGenome:RGD:1306575
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lrp157
Summary: Predicted to enable beta-tubulin binding activity; nucleic acid binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in regulation of mitochondrial translation. Predicted to act upstream of or within negative regulation of mitochondrial RNA catabolic process. Predicted to be located in several cellular components, including condensed nuclear chromosome; mitochondrial nucleoid; and perinuclear region of cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in French Canadian Leigh disease and Leigh disease. Orthologous to human LRPPRC (leucine rich pentatricopeptide repeat containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 568.4), Muscle (RPKM 416.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (15612638..15695113)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (9859816..9942294)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (7984043..8066874, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that rLRP157 is one of the proteins binding to, and regulating the activity of, the promoter of beta CaM kinase II.
Title: Rat leucine-rich protein binds and activates the promoter of the beta isoform of Ca2+/calmodulin-dependent protein kinase II gene.
LRP157, the rat orthologue of the human LRPPRC, may play a role in the modulation of peripheral pain transduction and serve as a novel marker for nociceptor subtypes.
Title: Isolation of an mRNA binding protein homologue that is expressed in nociceptors.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132068 (e-PCR)
- UniSTS:215351

D6Got4 (e-PCR)
- UniSTS:115570

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
NOT enables actin filament binding	ISO Inferred from Sequence Orthology more info
NOT enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-tubulin binding	IEA Inferred from Electronic Annotation more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial RNA catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of mitochondrial RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial RNA catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mitochondrial RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in condensed nuclear chromosome	IEA Inferred from Electronic Annotation more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine-rich PPR motif-containing protein, mitochondrial

Names: 130 kDa leucine-rich protein; LRP 130; leucine-rich PPR-motif containing; leucine-rich protein 157; rLRP157

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008519.2 → NP_001008519.2 leucine-rich PPR motif-containing protein, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q5SGE0

UniProtKB/TrEMBL

A6H9I4

Related

ENSRNOP00000008200.6, ENSRNOT00000008200.8

Conserved Domains (4) summary

PLN03218
Location:187 → 296

PLN03218; maturation of RBCL 1; Provisional

TIGR00756
Location:750 → 780

PPR; pentatricopeptide repeat domain (PPR motif)

sd00004
Location:198 → 225

PPR; PPR repeat [structural motif]

pfam13812
Location:147 → 206

PPR_3; Pentatricopeptide repeat domain