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    Uroc1 urocanate hydratase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685999, updated on 2-Nov-2024

    Summary

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    Symbol
    Uroc1provided by RGD
    Full Name
    urocanate hydratase 1provided by RGD
    Primary source
    RGD:1587777
    See related
    EnsemblRapid:ENSRNOG00000043404 AllianceGenome:RGD:1587777
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable urocanate hydratase activity. Predicted to be involved in L-histidine catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in urocanase deficiency. Orthologous to human UROC1 (urocanate hydratase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 434.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uroc1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (124402119..124433787)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (122844933..122876584)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (122244744..122276357)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486811 Neighboring gene similar to human chromosome 3 open reading frame 22 Neighboring gene carbohydrate sulfotransferase 13 Neighboring gene uncharacterized LOC134486812 Neighboring gene ZXD family zinc finger C Neighboring gene cilia and flagella associated protein 100

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in the urocanase gene UROC1 are associated with urocanic aciduria. Espinós C, et al. J Med Genet, 2009 Jun. PMID 19304569
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables urocanate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables urocanate hydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-histidine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-histidine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-histidine catabolic process to glutamate and formamide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-histidine catabolic process to glutamate and formate IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    urocanate hydratase; urocanate hydratase 1
    Names
    urocanase domain containing 1
    urocanate hydratase-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431883.1 → NP_001418812.1  urocanate hydratase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      D3ZIC2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      124402119..124433787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001066120.8 → XP_001066120.2  urocanate hydratase

      Related
      ENSRNOP00000032936.4, ENSRNOT00000038251.7
      Conserved Domains (1) summary
      PRK05414
      Location:74 → 662
      PRK05414; urocanate hydratase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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