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    Atp8a1 ATPase phospholipid transporting 8A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289615, updated on 2-Nov-2024

    Summary

    Official Symbol
    Atp8a1provided by RGD
    Official Full Name
    ATPase phospholipid transporting 8A1provided by RGD
    Primary source
    RGD:1309619
    See related
    EnsemblRapid:ENSRNOG00000034200 AllianceGenome:RGD:1309619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylserine flippase activity. Predicted to be involved in several processes, including learning; regulation of membrane lipid distribution; and synaptic vesicle endocytosis. Is active in synaptic vesicle membrane. Orthologous to human ATP8A1 (ATPase phospholipid transporting 8A1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 314.3), Lung (RPKM 276.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Atp8a1 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (40668932..40911465)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (40315013..40557572)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (41972398..42210555)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene glutaredoxin and cysteine rich domain containing 1 Neighboring gene uncharacterized LOC120096602 Neighboring gene uncharacterized LOC134481745 Neighboring gene shisa family member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylserine flippase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in aminophospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    phospholipid-transporting ATPase IA
    Names
    ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
    probable phospholipid-transporting ATPase IA
    NP_001413924.1
    XP_006251042.1
    XP_038948654.1
    XP_038948656.1
    XP_038948657.1
    XP_038948658.1
    XP_063128992.1
    XP_063128993.1
    XP_063128994.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426995.2NP_001413924.1  phospholipid-transporting ATPase IA

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AVY6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      40668932..40911465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092730.2XP_038948658.1  phospholipid-transporting ATPase IA isoform X4

      UniProtKB/TrEMBL
      A6JDA0
      Conserved Domains (1) summary
      TIGR01652
      Location:491096
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    2. XM_063272922.1XP_063128992.1  phospholipid-transporting ATPase IA isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZXX6
    3. XM_063272923.1XP_063128993.1  phospholipid-transporting ATPase IA isoform X6

    4. XM_039092726.2XP_038948654.1  phospholipid-transporting ATPase IA isoform X1

      UniProtKB/TrEMBL
      A6JDA0
      Conserved Domains (1) summary
      TIGR01652
      Location:941131
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    5. XM_039092729.2XP_038948657.1  phospholipid-transporting ATPase IA isoform X3

      UniProtKB/TrEMBL
      A6JDA0
      Conserved Domains (1) summary
      TIGR01652
      Location:941116
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    6. XM_039092728.2XP_038948656.1  phospholipid-transporting ATPase IA isoform X2

      UniProtKB/TrEMBL
      A6JDA0
      Conserved Domains (1) summary
      TIGR01652
      Location:941131
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    7. XM_006250980.4XP_006251042.1  phospholipid-transporting ATPase IA isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZKC1
      Related
      ENSRNOP00000077596.1, ENSRNOT00000099913.2
      Conserved Domains (5) summary
      TIGR01484
      Location:489654
      HAD-SF-IIB; HAD-superfamily hydrolase, subfamily IIB
      TIGR01494
      Location:14716
      ATPase_P-type; ATPase, P-type (transporting), HAD superfamily, subfamily IC
      pfam13246
      Location:322417
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16212
      Location:663915
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:632661
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    8. XM_063272924.1XP_063128994.1  phospholipid-transporting ATPase IA isoform X8

      Related
      ENSRNOP00000039929.6, ENSRNOT00000044017.7