Slc30a9 solute carrier family 30 member 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc30a9provided by RGD
Official Full Name: solute carrier family 30 member 9provided by RGD
Primary source: RGD:1593180
See related: EnsemblRapid:ENSRNOG00000002246 AllianceGenome:RGD:1593180
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including nuclear receptor binding activity; nuclear receptor coactivator activity; and zinc ion transmembrane transporter activity. Predicted to be involved in intracellular zinc ion homeostasis; regulation of mitochondrion organization; and zinc ion transport. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and mitochondrial membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human SLC30A9 (solute carrier family 30 member 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 314.4), Kidney (RPKM 228.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (41170164..41224861, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (40816284..40870992, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (42464814..42519760, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ZIP9-centered androgen pathway compensates for the 2605 MHz radiofrequency electromagnetic radiation-mediated reduction in resistance to H2O2 damage in Sertoli cells of adult rats.
Title: The ZIP9-centered androgen pathway compensates for the 2605 MHz radiofrequency electromagnetic radiation-mediated reduction in resistance to H(2)O(2) damage in Sertoli cells of adult rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proton-coupled zinc antiporter SLC30A9, mitochondrial

Names: solute carrier family 30 (zinc transporter), member 9; zinc transporter 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109088.1 → NP_001102558.1 proton-coupled zinc antiporter SLC30A9, mitochondrial

See identical proteins and their annotated locations for NP_001102558.1

Status: PROVISIONAL

Source sequence(s)

CH473981

UniProtKB/TrEMBL

A0A8I5ZUD8, A0A8I6AXK2, A6JDA5

Related

ENSRNOP00000082378.1, ENSRNOT00000100697.2

Conserved Domains (2) summary

TIGR00598
Location:123 → 208

rad14; DNA repair protein

pfam01545
Location:250 → 449

Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

41170164..41224861 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250963.4 → XP_006251025.1 proton-coupled zinc antiporter SLC30A9, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I6AXK2

Related

ENSRNOP00000093811.1, ENSRNOT00000097270.2

Conserved Domains (2) summary

TIGR00598
Location:122 → 207

rad14; DNA repair protein

pfam01545
Location:249 → 448

Cation_efflux; Cation efflux family