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    Mpi mannose phosphate isomerase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300741, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mpiprovided by RGD
    Official Full Name
    mannose phosphate isomeraseprovided by RGD
    Primary source
    RGD:3107
    See related
    EnsemblRapid:ENSRNOG00000018898 AllianceGenome:RGD:3107
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mannose-6-phosphate isomerase activity. Predicted to be involved in GDP-mannose biosynthetic process from fructose-6-phosphate; GDP-mannose biosynthetic process from glucose; and mannose to fructose-6-phosphate catabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 212.9), Muscle (RPKM 193.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mpi in Genome Data Viewer
    Location:
    8q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66843802..66852108, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57947883..57956205, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (62324176..62332080, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 5A Neighboring gene family with sequence similarity 219, member B Neighboring gene transfer RNA alanine (anticodon AGC) 55 Neighboring gene secretory carrier membrane protein 2 Neighboring gene unc-51 like kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Metabolically programmed quality control system for dolichol-linked oligosaccharides. Harada Y, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218558, Free PMC Article
    2. Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality. DeRossi C, et al. J Biol Chem, 2006 Mar 3. PMID 16339137
    3. Carbohydrate-deficient glycoprotein syndrome type Ib. Phosphomannose isomerase deficiency and mannose therapy. Niehues R, et al. J Clin Invest, 1998 Apr 1. PMID 9525984, Free PMC Article
    4. Polymorphism and linkage for mannosephosphate isomerase in Mus musculus. Nichols EA, et al. Biochem Genet, 1973 Jan. PMID 4693062
    5. Esterase-17 (ES-17): characterization and genetic location on chromosome 9 of a bis-p-nitrophenyl phosphate-resistant esterase of the house mouse (Mus musculus). Otto J, et al. Biochem Genet, 1983 Feb. PMID 6838491

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC94106

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mannose-6-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-6-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannose-6-phosphate isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mannose-6-phosphate isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-mannose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GDP-mannose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GDP-mannose biosynthetic process from fructose-6-phosphate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GDP-mannose biosynthetic process from fructose-6-phosphate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GDP-mannose biosynthetic process from glucose IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GDP-mannose biosynthetic process from glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mannose to fructose-6-phosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mannose to fructose-6-phosphate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mannose to fructose-6-phosphate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mannose to fructose-6-phosphate catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mannose-6-phosphate isomerase
    Names
    PMI
    phosphohexomutase
    phosphomannose isomerase
    NP_001004081.1
    XP_038937013.1
    XP_038937015.1
    XP_063121189.1
    XP_063121190.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004081.1 → NP_001004081.1  mannose-6-phosphate isomerase

      See identical proteins and their annotated locations for NP_001004081.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079111
      UniProtKB/Swiss-Prot
      Q68FX1
      UniProtKB/TrEMBL
      A0A8I6ARZ5, A6J4W0
      Related
      ENSRNOP00000025783.4, ENSRNOT00000025783.7
      Conserved Domains (2) summary
      COG1482
      Location:9 → 402
      ManA; Mannose-6-phosphate isomerase, class I [Carbohydrate transport and metabolism]
      pfam01238
      Location:6 → 381
      PMI_typeI; Phosphomannose isomerase type I

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      66843802..66852108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265119.1 → XP_063121189.1  mannose-6-phosphate isomerase isoform X3

    2. XM_039081087.2 → XP_038937015.1  mannose-6-phosphate isomerase isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKP8
      Related
      ENSRNOP00000093777.2, ENSRNOT00000113263.2
      Conserved Domains (1) summary
      pfam01238
      Location:6 → 323
      PMI_typeI; Phosphomannose isomerase type I

    3. XM_039081085.2 → XP_038937013.1  mannose-6-phosphate isomerase isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARZ5
      Conserved Domains (1) summary
      pfam01238
      Location:1 → 331
      PMI_typeI; Phosphomannose isomerase type I

    4. XM_063265120.1 → XP_063121190.1  mannose-6-phosphate isomerase isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FX1.1 GenPept UniProtKB/Swiss-Prot:Q68FX1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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