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    Tex264 testis expressed 264 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300988, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tex264provided by RGD
    Official Full Name
    testis expressed 264provided by RGD
    Primary source
    RGD:1359353
    See related
    EnsemblRapid:ENSRNOG00000013201 AllianceGenome:RGD:1359353
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in protein-DNA covalent cross-linking repair and reticulophagy. Predicted to be located in cytosol and endoplasmic reticulum. Predicted to be active in several cellular components, including autophagosome membrane; endoplasmic reticulum membrane; and replication fork. Orthologous to human TEX264 (testis expressed 264, ER-phagy receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 540.6), Adrenal (RPKM 168.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tex264 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (116174517..116201578, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107295806..107322858, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (115360706..115388299, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon AGA) 34 Neighboring gene glutamate metabotropic receptor 2 Neighboring gene RAD54 like 2 Neighboring gene translocase of inner mitochondrial membrane 8A1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tex264 Binding to SNX27 Regulates Itgα5 Receptor Membrane Recycling and Affects Cell Migration. Xu XH, et al. Biomed Res Int, 2022. PMID 35837377, Free PMC Article
    2. TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress. An H, et al. Mol Cell, 2019 Jun 6. PMID 31006537, Free PMC Article
    3. Tex261, a novel gene presumably related but distinct from steroidogenic acute regulatory (StAR) gene, is regulated during the development of germ cells. López-Fernández LA, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464256
    4. Intrinsically Disordered Protein TEX264 Mediates ER-phagy. Chino H, et al. Mol Cell, 2019 Jun 6. PMID 31006538
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tex264 Binding to SNX27 Regulates Itgalpha5 Receptor Membrane Recycling and Affects Cell Migration.
      Title: Tex264 Binding to SNX27 Regulates Itgα5 Receptor Membrane Recycling and Affects Cell Migration.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC94635

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein-DNA covalent cross-linking repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein-DNA covalent cross-linking repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within reticulophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reticulophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    testis-expressed protein 264
    Names
    putative secreted protein ZSIG11
    testis expressed gene 264 homolog
    testis-expressed sequence 264 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007665.1 → NP_001007666.1  testis-expressed protein 264

      See identical proteins and their annotated locations for NP_001007666.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083732
      UniProtKB/TrEMBL
      A0A8I5Y9A0, A6I2U9, A6I2V0, Q5XIF0
      Related
      ENSRNOP00000018122.3, ENSRNOT00000018122.7
      Conserved Domains (1) summary
      cl01368
      Location:45 → 112
      GyrI-like; GyrI-like small molecule binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      116174517..116201578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243726.5 → XP_006243788.1  testis-expressed protein 264 isoform X1

      See identical proteins and their annotated locations for XP_006243788.1

      UniProtKB/TrEMBL
      A0A8I5Y9A0, A6I2U9, A6I2V0, Q5XIF0
      Conserved Domains (1) summary
      cl01368
      Location:45 → 112
      GyrI-like; GyrI-like small molecule binding domain

    2. XM_039081211.2 → XP_038937139.1  testis-expressed protein 264 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y9A0, A6I2U9, A6I2V0, Q5XIF0
      Conserved Domains (1) summary
      cl01368
      Location:45 → 112
      GyrI-like; GyrI-like small molecule binding domain

    3. XM_006243727.5 → XP_006243789.1  testis-expressed protein 264 isoform X1

      See identical proteins and their annotated locations for XP_006243789.1

      UniProtKB/TrEMBL
      A0A8I5Y9A0, A6I2U9, A6I2V0, Q5XIF0
      Conserved Domains (1) summary
      cl01368
      Location:45 → 112
      GyrI-like; GyrI-like small molecule binding domain

    4. XM_008766501.3 → XP_008764723.1  testis-expressed protein 264 isoform X1

      See identical proteins and their annotated locations for XP_008764723.1

      UniProtKB/TrEMBL
      A0A8I5Y9A0, A6I2U9, A6I2V0, Q5XIF0
      Conserved Domains (1) summary
      cl01368
      Location:45 → 112
      GyrI-like; GyrI-like small molecule binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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