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    Tmem9 transmembrane protein 9 [ Mus musculus (house mouse) ]

    Gene ID: 66241, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem9provided by MGI
    Official Full Name
    transmembrane protein 9provided by MGI
    Primary source
    MGI:MGI:1913491
    See related
    Ensembl:ENSMUSG00000026411 AllianceGenome:MGI:1913491
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500015G18Rik
    Summary
    Involved in positive regulation of canonical Wnt signaling pathway and regulation of protein catabolic process. Predicted to be located in bounding membrane of organelle; intercellular bridge; and mitotic spindle. Is expressed in central nervous system; retina; small intestine; and tooth. Orthologous to human TMEM9 (transmembrane protein 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 68.3), kidney adult (RPKM 56.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem9 in Genome Data Viewer
    Location:
    1 E4; 1 59.51 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135935957..135962768)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (136008219..136035030)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene troponin T2, cardiac Neighboring gene STARR-seq mESC enhancer starr_02397 Neighboring gene plakophilin 1 Neighboring gene immunoglobulin-like and fibronectin type III domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02398 Neighboring gene STARR-seq mESC enhancer starr_02399 Neighboring gene STARR-positive B cell enhancer ABC_E10039 Neighboring gene STARR-positive B cell enhancer ABC_E4348 Neighboring gene calcium channel, voltage-dependent, L type, alpha 1S subunit Neighboring gene achaete-scute family bHLH transcription factor 5 Neighboring gene STARR-seq mESC enhancer starr_02400

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the novel human transmembrane protein 9 (TMEM9) that localizes to lysosomes and late endosomes. Kveine M, et al. Biochem Biophys Res Commun, 2002 Oct 4. PMID 12359240
    2. TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis. Jung YS, et al. Hepatology, 2021 Feb. PMID 32380568, Free PMC Article
    3. TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling. Jung YS, et al. Nat Cell Biol, 2018 Dec. PMID 30374053, Free PMC Article
    4. p57Kip2 expression is enhanced during mid-cardiac murine development and is restricted to trabecular myocardium. Kochilas LK, et al. Pediatr Res, 1999 May. PMID 10231856
    5. Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Van Dyck F, et al. Cell Metab, 2007 Nov. PMID 17983586

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM9-v-ATPase Activates Wnt/beta-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
      Title: TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosomal lumen acidification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal lumen acidification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lysosomal lumen acidification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosomal lumen acidification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton-transporting V-type ATPase complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton-transporting V-type ATPase complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in multivesicular body membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in multivesicular body membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proton-transporting V-type ATPase complex assembly regulator TMEM9
    Names
    v-ATPase assembly regulator TMEM9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160145.1 → NP_001153617.1  proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor

      See identical proteins and their annotated locations for NP_001153617.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AC108813, AC124375, BQ918002
      Consensus CDS
      CCDS15323.1
      UniProtKB/Swiss-Prot
      Q3U459, Q9CR23
      Related
      ENSMUSP00000128185.2, ENSMUST00000165125.8
      Conserved Domains (1) summary
      pfam05434
      Location:44 → 182
      Tmemb_9; TMEM9

    2. NM_001160146.1 → NP_001153618.1  proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor

      See identical proteins and their annotated locations for NP_001153618.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC108813, AC124375, CX208138
      Consensus CDS
      CCDS15323.1
      UniProtKB/Swiss-Prot
      Q3U459, Q9CR23
      Related
      ENSMUSP00000113416.2, ENSMUST00000117950.2
      Conserved Domains (1) summary
      pfam05434
      Location:44 → 182
      Tmemb_9; TMEM9

    3. NM_025439.3 → NP_079715.1  proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor

      See identical proteins and their annotated locations for NP_079715.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC108813, AC124375, CA460035
      Consensus CDS
      CCDS15323.1
      UniProtKB/Swiss-Prot
      Q3U459, Q9CR23
      Related
      ENSMUSP00000065409.9, ENSMUST00000063719.15
      Conserved Domains (1) summary
      pfam05434
      Location:44 → 182
      Tmemb_9; TMEM9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      135935957..135962768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR23.1 GenPept UniProtKB/Swiss-Prot:Q9CR23

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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