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    Castor1 cytosolic arginine sensor for mTORC1 subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 71962, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Castor1provided by MGI
    Official Full Name
    cytosolic arginine sensor for mTORC1 subunit 1provided by MGI
    Primary source
    MGI:MGI:1919212
    See related
    Ensembl:ENSMUSG00000020424 AllianceGenome:MGI:1919212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gatsl3; 2410008K03Rik
    Summary
    Predicted to enable several functions, including arginine binding activity; identical protein binding activity; and protein sequestering activity. Predicted to be involved in cellular response to L-arginine; cellular response to amino acid starvation; and regulation of TORC1 signaling. Predicted to be part of GATOR2 complex. Predicted to be active in cytosol. Is expressed in several structures, including Harderian gland; foregut; genitourinary system; skin; and trigeminal nerve. Orthologous to human CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 12.0), lung adult (RPKM 10.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Castor1 in Genome Data Viewer
    Location:
    11 A1; 11 2.94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4167401..4172409)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4218166..4222409)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 215 Neighboring gene microRNA 3060 Neighboring gene coiled-coil domain containing 157 Neighboring gene splicing factor 3a, subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E727 Neighboring gene TBC1 domain family, member 10a Neighboring gene STARR-positive B cell enhancer ABC_E2978 Neighboring gene predicted gene 11956 Neighboring gene oncostatin M

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter. Iskarpatyoti JA, et al. Cell Rep, 2022 Sep 27. PMID 36170813, Free PMC Article
    2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter.
      Title: Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141006

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arginine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arginine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular sensor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein sequestering activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to L-arginine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to L-arginine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to L-arginine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to amino acid starvation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of GATOR2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of GATOR2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic arginine sensor for mTORC1 subunit 1
    Names
    GATS protein-like 3
    GATS-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028022.2 → NP_082298.1  cytosolic arginine sensor for mTORC1 subunit 1

      See identical proteins and their annotated locations for NP_082298.1

      Status: VALIDATED

      Source sequence(s)
      AK010455, BC039988, CN719833
      Consensus CDS
      CCDS24381.1
      UniProtKB/Swiss-Prot
      Q29R56, Q9CWQ8
      Related
      ENSMUSP00000020699.4, ENSMUST00000020699.4
      Conserved Domains (1) summary
      pfam13840
      Location:260 → 321
      ACT_7; ACT domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      4167401..4172409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157005.1 → XP_036012898.1  cytosolic arginine sensor for mTORC1 subunit 1 isoform X1

      Conserved Domains (2) summary
      pfam13840
      Location:204 → 268
      ACT_7; ACT domain
      pfam18700
      Location:1 → 16
      Castor1_N; Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain

    2. XM_011243752.4 → XP_011242054.1  cytosolic arginine sensor for mTORC1 subunit 1 isoform X1

      Conserved Domains (2) summary
      pfam13840
      Location:204 → 268
      ACT_7; ACT domain
      pfam18700
      Location:1 → 16
      Castor1_N; Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWQ8.1 GenPept UniProtKB/Swiss-Prot:Q9CWQ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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