Psmg1 proteasome (prosome, macropain) assembly chaperone 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmg1provided by MGI
Official Full Name: proteasome (prosome, macropain) assembly chaperone 1provided by MGI
Primary source: MGI:MGI:1860263
See related: Ensembl:ENSMUSG00000022913 AllianceGenome:MGI:1860263
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dscr2
Summary: Enables proteasome binding activity. Acts upstream of or within cerebellar granule cell precursor proliferation and proteasome core complex assembly. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of protein folding chaperone complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human PSMG1 (proteasome assembly chaperone 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 32.4), placenta adult (RPKM 19.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 56.76 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (95781133..95792160, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (95979933..95990960, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dscr2 (e-PCR), detects polymorphism
- UniSTS:259073

AW552102 (e-PCR)
- UniSTS:180953

Fgf1 (e-PCR), detects polymorphism
- UniSTS:527349

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cerebellar granule cell precursor proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaperone-mediated protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome core complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteasome core complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of protein folding chaperone complex	IEA Inferred from Electronic Annotation more info
part_of protein folding chaperone complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proteasome assembly chaperone 1

Names: Down syndrome critical region homolog 2; down syndrome critical region protein 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.