Ifit3 interferon-induced protein with tetratricopeptide repeats 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ifit3provided by RGD
Official Full Name: interferon-induced protein with tetratricopeptide repeats 3provided by RGD
Primary source: RGD:1359681
See related: Ensembl:ENSRNOG00000022839 AllianceGenome:RGD:1359681
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity and identical protein binding activity. Predicted to be involved in defense response to virus; negative regulation of apoptotic process; and negative regulation of cell population proliferation. Predicted to act upstream of or within cellular response to interferon-beta; response to bacterium; and response to stilbenoid. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Orthologous to human IFIT3 (interferon induced protein with tetratricopeptide repeats 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 143.9), Lung (RPKM 86.3) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1q53

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (241527326..241532469)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (232114166..232119311)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (252906234..252911377)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to stilbenoid	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon-induced protein with tetratricopeptide repeats 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007694.3 → NP_001007695.1 interferon-induced protein with tetratricopeptide repeats 3

See identical proteins and their annotated locations for NP_001007695.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

Q6AYE7

Related

ENSRNOP00000033267.3, ENSRNOT00000031025.5

Conserved Domains (3) summary

sd00006
Location:206 → 236

TPR; TPR repeat [structural motif]

pfam13424
Location:51 → 126

TPR_12; Tetratricopeptide repeat

pfam14559
Location:217 → 281

TPR_19; Tetratricopeptide repeat