U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Insyn1 inhibitory synaptic factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 319477, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Insyn1provided by MGI
    Official Full Name
    inhibitory synaptic factor 1provided by MGI
    Primary source
    MGI:MGI:2442108
    See related
    Ensembl:ENSMUSG00000066607 AllianceGenome:MGI:2442108
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6030419C18Rik
    Summary
    Involved in inhibitory postsynaptic potential and postsynaptic specialization organization. Located in postsynaptic density. Is active in GABA-ergic synapse and postsynaptic specialization. Orthologous to human INSYN1 (inhibitory synaptic factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 36.6), cerebellum adult (RPKM 35.6) and 13 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Insyn1 in Genome Data Viewer
    Location:
    9 B; 9 31.79 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (58395886..58407063)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58488603..58499780)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930461G14 gene Neighboring gene STARR-seq mESC enhancer starr_24279 Neighboring gene predicted gene, 32820 Neighboring gene predicted gene, 32768 Neighboring gene STARR-positive B cell enhancer ABC_E6742 Neighboring gene predicted gene, 53528 Neighboring gene CD276 antigen Neighboring gene STARR-positive B cell enhancer ABC_E1387 Neighboring gene neuroplastin Neighboring gene REC114 meiotic recombination protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice. Uezu A, et al. Elife, 2019 Dec 12. PMID 31829939, Free PMC Article
    2. Identification of an elaborate complex mediating postsynaptic inhibition. Uezu A, et al. Science, 2016 Sep 9. PMID 27609886, Free PMC Article
    3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission, postsynaptic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission, postsynaptic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inhibitory postsynaptic potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inhibitory postsynaptic potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynaptic specialization organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynaptic specialization organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic specialization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    inhibitory synaptic factor 1
    Names
    UPF0583 protein C15orf59 homolog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176921.4 → NP_795895.1  inhibitory synaptic factor 1

      See identical proteins and their annotated locations for NP_795895.1

      Status: VALIDATED

      Source sequence(s)
      AK031382, BC096614
      Consensus CDS
      CCDS23243.1
      UniProtKB/Swiss-Prot
      Q8CD60
      Related
      ENSMUSP00000082800.5, ENSMUST00000085658.5
      Conserved Domains (2) summary
      pfam15252
      Location:52 → 279
      DUF4589; Domain of unknown function (DUF4589)
      pfam13654
      Location:21 → 64
      AAA_32; AAA domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      58395886..58407063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CD60.1 GenPept UniProtKB/Swiss-Prot:Q8CD60

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools