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    SEC22B SEC22 homolog B, vesicle trafficking protein [ Homo sapiens (human) ]

    Gene ID: 9554, updated on 28-Oct-2024

    Summary

    Official Symbol
    SEC22Bprovided by HGNC
    Official Full Name
    SEC22 homolog B, vesicle trafficking proteinprovided by HGNC
    Primary source
    HGNC:HGNC:10700
    See related
    Ensembl:ENSG00000265808 MIM:604029; AllianceGenome:HGNC:10700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERS-24; SEC22L1
    Summary
    The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009]
    Expression
    Ubiquitous expression in thyroid (RPKM 13.3), fat (RPKM 13.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SEC22B in Genome Data Viewer
    Location:
    1p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (120150898..120176520, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (120164165..120189787, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (120693460..120697156, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929178 Neighboring gene NANOG hESC enhancer GRCh37_chr1:120623938-120624439 Neighboring gene RNA, U6 small nuclear 465, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:145096721-145097286 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:145096155-145096720 Neighboring gene uncharacterized LOC100996723 Neighboring gene NANOG hESC enhancer GRCh37_chr1:144689698-144690199 Neighboring gene uncharacterized LOC124904391 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:144504660-144505204 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:144533587-144533917 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:144533911-144534909 Neighboring gene U1 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with SEC22B; predicted interaction to be within the endoplasmic reticulum to Golgi transport PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ER to Golgi transport vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane TAS
    Traceable Author Statement
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in phagocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in transport vesicle TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    vesicle-trafficking protein SEC22b
    Names
    ER-Golgi SNARE of 24 kDa
    SEC22 vesicle trafficking protein homolog B
    SEC22 vesicle trafficking protein-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004892.6NP_004883.3  vesicle-trafficking protein SEC22b

      See identical proteins and their annotated locations for NP_004883.3

      Status: REVIEWED

      Source sequence(s)
      AA135767, AC245008, AI085383, AK289875, BU741516, CD619408
      Consensus CDS
      CCDS83523.1
      UniProtKB/Swiss-Prot
      A8K1G0, O75396
      Related
      ENSP00000463393.1, ENST00000578049.4
      Conserved Domains (2) summary
      cd15866
      Location:132195
      R-SNARE_SEC22; SNARE motif of SEC22
      cd14824
      Location:3126
      Longin; longin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      120150898..120176520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      120164165..120189787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)