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    TXNDC11 thioredoxin domain containing 11 [ Homo sapiens (human) ]

    Gene ID: 51061, updated on 28-Oct-2024

    Summary

    Official Symbol
    TXNDC11provided by HGNC
    Official Full Name
    thioredoxin domain containing 11provided by HGNC
    Primary source
    HGNC:HGNC:28030
    See related
    Ensembl:ENSG00000153066 MIM:617792; AllianceGenome:HGNC:28030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EFP1
    Summary
    Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in fat (RPKM 51.7), thyroid (RPKM 30.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TXNDC11 in Genome Data Viewer
    Location:
    16p13.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11679083..11742857, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11715131..11778900, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11772939..11836713, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11654074-11654928 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11656029-11656658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11657289-11657918 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11657919-11658546 Neighboring gene lipopolysaccharide induced TNF factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11665841-11666778 Neighboring gene Sharpr-MPRA regulatory region 2706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10450 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7205 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11688769-11689642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11689643-11690514 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11697089-11697681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11699131-11699630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10451 Neighboring gene Sharpr-MPRA regulatory region 4417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11708187-11708794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11708795-11709402 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11715855-11716623 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11720940-11721474 Neighboring gene Sharpr-MPRA regulatory region 8349 Neighboring gene uncharacterized LOC124903643 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11735633-11736296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11766535-11767354 Neighboring gene nonconserved acetylation island sequence 94 enhancer Neighboring gene stannin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10456 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11836693-11837215 Neighboring gene TXNDC11 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10457 Neighboring gene zinc finger CCCH-type containing 7A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7209 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11890813-11891350

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    thioredoxin domain-containing protein 11
    Names
    EF-hand binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303447.2NP_001290376.1  thioredoxin domain-containing protein 11 isoform 1

      See identical proteins and their annotated locations for NP_001290376.1

      Status: VALIDATED

      Source sequence(s)
      BC002856, BC013727, CN347909
      Consensus CDS
      CCDS76822.1
      UniProtKB/Swiss-Prot
      O95887, Q6PJA6, Q6PKC3, Q8N2Q4, Q96K45, Q96K53
      Related
      ENSP00000349439.3, ENST00000356957.7
      Conserved Domains (3) summary
      cd02995
      Location:692794
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cd03006
      Location:97209
      PDI_a_EFP1_N; PDIa family, N-terminal EFP1 subfamily; EFP1 is a binding partner protein of thyroid oxidase (ThOX), also called Duox. ThOX proteins are responsible for the generation of hydrogen peroxide, a crucial substrate of thyroperoxidase, which functions to ...
      cl23720
      Location:830915
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_001324022.2NP_001310951.1  thioredoxin domain-containing protein 11 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC007613
      UniProtKB/TrEMBL
      B4DLP5
      Conserved Domains (2) summary
      cd02995
      Location:451553
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cl23720
      Location:589674
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. NM_001324024.2NP_001310953.1  thioredoxin domain-containing protein 11 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC007613
      UniProtKB/Swiss-Prot
      Q6PKC3
      Conserved Domains (2) summary
      cd02995
      Location:213315
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cl23720
      Location:351436
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    4. NM_001324025.2NP_001310954.1  thioredoxin domain-containing protein 11 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC007613
      UniProtKB/Swiss-Prot
      Q6PKC3
      Conserved Domains (2) summary
      cd02995
      Location:213315
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cl23720
      Location:351436
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    5. NM_015914.7NP_056998.4  thioredoxin domain-containing protein 11 isoform 2

      See identical proteins and their annotated locations for NP_056998.4

      Status: VALIDATED

      Source sequence(s)
      AF131780, AK027646, CN347909
      Consensus CDS
      CCDS32387.1
      UniProtKB/Swiss-Prot
      Q6PKC3
      Related
      ENSP00000283033.5, ENST00000283033.10
      Conserved Domains (4) summary
      cd02981
      Location:219323
      PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02995
      Location:665767
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cd03006
      Location:97209
      PDI_a_EFP1_N; PDIa family, N-terminal EFP1 subfamily; EFP1 is a binding partner protein of thyroid oxidase (ThOX), also called Duox. ThOX proteins are responsible for the generation of hydrogen peroxide, a crucial substrate of thyroperoxidase, which functions to ...
      cl23720
      Location:803888
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RNA

    1. NR_136671.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007613
    2. NR_136672.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007613
    3. NR_136673.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007613
    4. NR_136674.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007613

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      11679083..11742857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522515.3XP_011520817.1  thioredoxin domain-containing protein 11 isoform X1

      Conserved Domains (3) summary
      cd02995
      Location:705807
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cd03006
      Location:97209
      PDI_a_EFP1_N; PDIa family, N-terminal EFP1 subfamily; EFP1 is a binding partner protein of thyroid oxidase (ThOX), also called Duox. ThOX proteins are responsible for the generation of hydrogen peroxide, a crucial substrate of thyroperoxidase, which functions to ...
      cl23720
      Location:843928
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. XM_047434191.1XP_047290147.1  thioredoxin domain-containing protein 11 isoform X2

    3. XM_047434192.1XP_047290148.1  thioredoxin domain-containing protein 11 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      11715131..11778900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380431.1XP_054236406.1  thioredoxin domain-containing protein 11 isoform X1

    2. XM_054380432.1XP_054236407.1  thioredoxin domain-containing protein 11 isoform X2

    3. XM_054380433.1XP_054236408.1  thioredoxin domain-containing protein 11 isoform X3