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    PBA1 Pba1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850896, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PBA1
    Official Full Name
    Pba1p
    Primary source
    SGD:S000004189
    Locus tag
    YLR199C
    See related
    AllianceGenome:SGD:S000004189; FungiDB:YLR199C; VEuPathDB:YLR199C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    POC1
    Summary
    Involved in proteasome assembly. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PBA1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    2
    Sequence:
    Chromosome: XII; NC_001144.5 (547853..548769, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene rRNA-processing protein PWP1 Neighboring gene snoRNP complex protein NOP56 Neighboring gene tubulin-binding prefolding complex subunit YKE2 Neighboring gene ubiquinone biosynthesis protein COQ9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of proteasome gate modulation by assembly chaperones Pba1 and Pba2. Schnell HM, et al. J Biol Chem, 2022 May. PMID 35398095, Free PMC Article
    2. Structure of a proteasome Pba1-Pba2 complex: implications for proteasome assembly, activation, and biological function. Stadtmueller BM, et al. J Biol Chem, 2012 Oct 26. PMID 22930756, Free PMC Article
    3. A conserved 20S proteasome assembly factor requires a C-terminal HbYX motif for proteasomal precursor binding. Kusmierczyk AR, et al. Nat Struct Mol Biol, 2011 May. PMID 21499243, Free PMC Article
    4. Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis. Schnell HM, et al. Nat Struct Mol Biol, 2021 May. PMID 33846632, Free PMC Article
    5. Hsp70 and Hsp110 Chaperones Promote Early Steps of Proteasome Assembly. Matias AC, et al. Biomolecules, 2022 Dec 21. PMID 36671396, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanism of proteasome gate modulation by assembly chaperones Pba1 and Pba2.
      Title: Mechanism of proteasome gate modulation by assembly chaperones Pba1 and Pba2.
    2. Ump1 and Pba1-Pba2 promote efficient biogenesis of 20S proteasome core particles from its subunits via 15S intermediates
      Title: Proteasome assembly from 15S precursors involves major conformational changes and recycling of the Pba1-Pba2 chaperone.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteasome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pba1p
    NP_013300.2
    • Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      547853..548769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182086.1 → NP_013300.2  TPA: Pba1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013300.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYK1, Q05778
      UniProtKB/TrEMBL
      B3RH89, C7GIT0, C8ZDG5, N1NZE2
      Conserved Domains (1) summary
      pfam10450
      Location:1 → 276
      POC1; POC1 chaperone
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05778.2

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