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    GPI17 GPI-anchor transamidase GPI17 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852044, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GPI17
    Official Full Name
    GPI-anchor transamidase GPI17
    Primary source
    SGD:S000002842
    Locus tag
    YDR434W
    See related
    AllianceGenome:SGD:S000002842; FungiDB:YDR434W; VEuPathDB:YDR434W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in attachment of GPI anchor to protein. Located in endoplasmic reticulum and nuclear inner membrane. Is integral component of membrane. Part of GPI-anchor transamidase complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human PIGS (phosphatidylinositol glycan anchor biosynthesis class S). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GPI17 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1331237..1332841)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene pitrilysin family metalloprotease Neighboring gene mRNA-binding protein NPL3 Neighboring gene leucine carboxy methyltransferase Neighboring gene salt homeostasis regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and crystallization of yeast glycosylphosphatidylinositol transamidase subunit PIG-S (PIG-S(71-467)). Kamariah N, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Aug 1. PMID 21821889, Free PMC Article
    2. Structural insight into the glycosylphosphatidylinositol transamidase subunits PIG-K and PIG-S from yeast. Toh YK, et al. J Struct Biol, 2011 Feb. PMID 21134462
    3. Deficiencies in the endoplasmic reticulum (ER)-membrane protein Gab1p perturb transfer of glycosylphosphatidylinositol to proteins and cause perinuclear ER-associated actin bar formation. Grimme SJ, et al. Mol Biol Cell, 2004 Jun. PMID 15075373, Free PMC Article
    4. Gpi17p does not stably interact with other subunits of glycosylphosphatidylinositol transamidase in Saccharomyces cerevisiae. Zhu Y, et al. Biochim Biophys Acta, 2005 Jun 15. PMID 15939668
    5. Disulfide Bond Formation and N-Glycosylation Modulate Protein-Protein Interactions in GPI-Transamidase (GPIT). Yi L, et al. Sci Rep, 2017 Apr 4. PMID 28374821, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of GPI anchor to protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in attachment of GPI anchor to protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GPI-anchor transamidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GPI-anchor transamidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GPI-anchor transamidase GPI17
    NP_010722.3
    • Transmembrane protein; subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1331237..1332841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180742.3 → NP_010722.3  TPA: GPI-anchor transamidase GPI17 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010722.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT61, Q04080
      UniProtKB/TrEMBL
      B3LFM5, B5VGW5, C7GTN8, C8Z5Z5, N1P8W9
      Conserved Domains (1) summary
      pfam10510
      Location:13 → 502
      PIG-S; Phosphatidylinositol-glycan biosynthesis class S protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04080.1

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