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    TSR4 Tsr4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854136, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TSR4
    Official Full Name
    Tsr4p
    Primary source
    SGD:S000005382
    Locus tag
    YOL022C
    See related
    AllianceGenome:SGD:S000005382; FungiDB:YOL022C; VEuPathDB:YOL022C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables unfolded protein binding activity. Involved in maturation of SSU-rRNA. Located in cytoplasm. Orthologous to several human genes including PDCD2 (programmed cell death 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TSR4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (280272..281498, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene translation initiation factor 2 Neighboring gene tRNA-Gly Neighboring gene exosome catalytic subunit DIS3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the DNA sequence of a 34,038 bp region on the left arm of yeast chromosome XV. Rad MR, et al. Yeast, 1997 Mar 15. PMID 9090058
    2. yRACK1/Asc1 proxiOMICs-Towards Illuminating Ships Passing in the Night. Schmitt K, et al. Cells, 2019 Nov 4. PMID 31689955, Free PMC Article
    3. Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Ben-Aroya S, et al. Mol Cell, 2008 Apr 25. PMID 18439903, Free PMC Article
    4. Tsr4 Is a Cytoplasmic Chaperone for the Ribosomal Protein Rps2 in Saccharomyces cerevisiae. Black JJ, et al. Mol Cell Biol, 2019 Sep 1. PMID 31182640, Free PMC Article
    5. The rRNA methyltransferase Bud23 shows functional interaction with components of the SSU processome and RNase MRP. Sardana R, et al. RNA, 2013 Jun. PMID 23604635, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables unfolded protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tsr4p
    NP_014620.1
    • Cytoplasmic assembly chaperone for ribosomal protein Rps2p; co-translationally associates with the N-terminal extension of Rps2p to facilitate expression, solubility and ribosome assembly; released prior to the nuclear import of Rps2p; required for correct processing of 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in the S288C background but not in CEN.PK2; homologous to human PDCD2L and PDCD2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      280272..281498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183276.2 → NP_014620.1  TPA: Tsr4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014620.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W243, P25040
      UniProtKB/TrEMBL
      B3LJ34, B5VRM9, C7GJZ3, C8ZHU1, G2WMK9, N1NWS1
      Conserved Domains (1) summary
      pfam04194
      Location:282 → 404
      PDCD2_C; Programmed cell death protein 2, C-terminal putative domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25040.2

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