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    RAM2 bifunctional protein farnesyltransferase/protein geranylgeranyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853849, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RAM2
    Official Full Name
    bifunctional protein farnesyltransferase/protein geranylgeranyltransferase
    Primary source
    SGD:S000001502
    Locus tag
    YKL019W
    See related
    AllianceGenome:SGD:S000001502; FungiDB:YKL019W; VEuPathDB:YKL019W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables CAAX-protein geranylgeranyltransferase activity and protein farnesyltransferase activity. Involved in peptide pheromone maturation; protein farnesylation; and protein geranylgeranylation. Part of CAAX-protein geranylgeranyltransferase complex and protein farnesyltransferase complex. Orthologous to human FNTA (farnesyltransferase, CAAX box, alpha). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RAM2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (402568..403518)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mak11p Neighboring gene Spt23p Neighboring gene Mco12p Neighboring gene WD-repeat containing protein SWD2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of yeast geranylgeranyl transferase I defect by alternative prenylation of two target GTPases, Rho1p and Cdc42p. Ohya Y, et al. Mol Biol Cell, 1993 Oct. PMID 8298188, Free PMC Article
    2. Sequence dependence of protein isoprenylation. Moores SL, et al. J Biol Chem, 1991 Aug 5. PMID 1860864
    3. Modulation of the zinc(II) center in protein farnesyltransferase by mutagenesis of the zinc(II) ligands. Harris CM, et al. Biochemistry, 2002 Aug 20. PMID 12173942
    4. Yeast protein farnesyltransferase. pKas of peptide substrates bound as zinc thiolates. Rozema DB, et al. Biochemistry, 1999 Oct 5. PMID 10529185
    5. SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Nislow C, et al. Mol Biol Cell, 1997 Dec. PMID 9398665, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables CAAX-protein geranylgeranyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CAAX-protein geranylgeranyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein farnesyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein farnesyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein geranylgeranyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein geranylgeranyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide pheromone maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptide pheromone maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein farnesylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein geranylgeranylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein prenylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CAAX-protein geranylgeranyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CAAX-protein geranylgeranyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein farnesyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein farnesyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional protein farnesyltransferase/protein geranylgeranyltransferase
    NP_012906.3
    • Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I; farnesyltransferase (Ram2p-Ram1p heterodimer) catalyzes the addition of 15-carbon isoprenoid farnesyl to substrate proteins containing a CAAX consensus motif; type I geranylgeranyltransferase (Ram2p-Cdc43p heterodimer) catalyzes the addition of the 20-carbon isoprenoid geranylgeranyl to substrate proteins containing a CaaL consensus motif; required for membrane localization of Ras proteins and a-factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      402568..403518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179585.3 → NP_012906.3  TPA: bifunctional protein farnesyltransferase/protein geranylgeranyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012906.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXR6, P29703
      UniProtKB/TrEMBL
      A6ZZU5, B3LR65, B5VMD6, C7GRH9, C8ZCE8, G2WI11, N1P0Q7
      Conserved Domains (1) summary
      COG5536
      Location:1 → 316
      BET4; Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29703.1

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