ARE2 sterol acyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ARE2
Official Full Name: sterol acyltransferase
Primary source: SGD:S000005302
Locus tag: YNR019W
See related: AllianceGenome:SGD:S000005302; FungiDB:YNR019W; VEuPathDB:YNR019W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SAT1
Summary: Enables ergosterol O-acyltransferase activity. Involved in ergosterol metabolic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Chagas disease; cardiomyopathy; congenital diarrhea 7 with exudative enteropathy; coronary artery disease; and hepatocellular carcinoma. Orthologous to several human genes including SOAT1 (sterol O-acyltransferase 1) and SOAT2 (sterol O-acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ARE2 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (665339..667267)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Are2p, Aus1p, and Pdr11p, unlike the minor acyltransferase, Are1p, colocalize to sterol and sphingolipid-enriched, detergent-resistant microdomains (DRMs).
Title: ATP-binding cassette transporters and sterol O-acyltransferases interact at membrane microdomains to modulate sterol uptake and esterification.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables ergosterol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ergosterol O-acyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ergosterol O-acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ergosterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ergosterol metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ergosterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sterol acyltransferase

NP_014416.1

Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

665339..667267

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183196.1 → NP_014416.1 TPA: sterol acyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014416.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1J4, P53629, Q12673

UniProtKB/TrEMBL

A6ZS93, B3LPM3, C7GLN6, C8ZFP6, G2WL76

Conserved Domains (1) summary

COG5056
Location:106 → 642

ARE1; Acyl-CoA cholesterol acyltransferase [Lipid metabolism]