TOM40 Tom40p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: TOM40
Gene description: Tom40p
Primary source: FungiDB:YMR203W
Locus tag: YMR203W
See related: SGD:S000004816; AllianceGenome:SGD:S000004816; VEuPathDB:YMR203W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ISP42; MOM38
Summary: Enables protein transmembrane transporter activity. Involved in protein import into mitochondrial matrix. Located in mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to several human genes including TOMM40 (translocase of outer mitochondrial membrane 40). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TOM40 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (668492..669655)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural snapshot of the mitochondrial protein import gate.
Title: Structural snapshot of the mitochondrial protein import gate.
Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex.
Title: Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex.
The dimeric mitochondrial protein-import channel TOM complex consists of two copies each of five proteins arranged in two-fold symmetry: pore-forming beta-barrel protein Tom40 and four auxiliary alpha-helical transmembrane proteins.
Title: Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution.
uncover the general preprotein translocase of the outer membrane (TOM) subunit Tom40 as the direct binding partner of Vps39 on mitochondria
Title: Vps39 Interacts with Tom40 to Establish One of Two Functionally Distinct Vacuole-Mitochondria Contact Sites.
Results show the relation between the identified presequence-binding region of Tom40 and the intermembrane space domain of Tom22. The identified presequence of Tom40 is capable of functioning independently of trans-acting TOM presequence-binding domain.
Title: Presequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrix.
Tom40 movement in the outer mitochondrial membrane is highly dynamic but confined in nature, suggesting anchoring of the TOM complex as a whole
Title: Single molecule tracking fluorescence microscopy in mitochondria reveals highly dynamic but confined movement of Tom40.
Tom7 recruits Mdm10, enhancing its association with the MMM1 complex, to regulate timing of the release of Tom40 from the TOB complex for subsequent assembly into the TOM40 complex
Title: Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40.
Daya suggest that the assembly of newly imported Tom40 is directly initiated at the SAM complex (SAM37) by its association with Tom5.
Title: Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction of Tom40 with the SAM complex.
Mdm10 regulates the timing of release of unassembled Tom40 from the TOB complex, to facilitate its coordinated assembly into the TOM40 complex
Title: Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40.
Dat show that biogenesis of the beta-barrel protein Tom40 and their membrane insertion and assembly required Mim1.
Title: Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables porin activity	IEA Inferred from Electronic Annotation more info
enables protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial matrix	IEA Inferred from Electronic Annotation more info
involved_in protein import into mitochondrial matrix	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
part_of mitochondrial outer membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial outer membrane translocase complex	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of pore complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Tom40p

NP_013930.1

Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore; pre-Tom40p is phosphorylated by PKA, which impairs its import into mitochondria under non-respiratory conditions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

668492..669655

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182710.1 → NP_013930.1 TPA: Tom40p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013930.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W028, P23644, Q6B1Q9

UniProtKB/TrEMBL

A6ZMR5, B3LM91, B5VPX1, C7GRE8, C8ZF68, N1P5T3

Conserved Domains (1) summary

cd07305
Location:57 → 360

Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)