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    EIS1 Eis1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855047, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EIS1
    Official Full Name
    Eis1p
    Primary source
    SGD:S000004633
    Locus tag
    YMR031C
    See related
    AllianceGenome:SGD:S000004633; FungiDB:YMR031C; VEuPathDB:YMR031C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in eisosome assembly. Located in mitochondrion and plasma membrane. Colocalizes with eisosome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See EIS1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (332212..334743, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Far8p Neighboring gene Rsf1p Neighboring gene formin-binding protein HOF1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Seg1 controls eisosome assembly and shape. Moreira KE, et al. J Cell Biol, 2012 Aug 6. PMID 22869600, Free PMC Article
    2. Plasma membrane microdomains regulate turnover of transport proteins in yeast. Grossmann G, et al. J Cell Biol, 2008 Dec 15. PMID 19064668, Free PMC Article
    3. Fungal BLAST and Model Organism BLASTP Best Hits: new comparison resources at the Saccharomyces Genome Database (SGD). Balakrishnan R, et al. Nucleic Acids Res, 2005 Jan 1. PMID 15608219, Free PMC Article
    4. A role for eisosomes in maintenance of plasma membrane phosphoinositide levels. Fröhlich F, et al. Mol Biol Cell, 2014 Sep 15. PMID 25057013, Free PMC Article
    5. Unifying fluorescence microscopy and mass spectrometry for studying protein complexes in cells. Deng C, et al. Mol Cell Proteomics, 2009 Jun. PMID 19269952, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in eisosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eisosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in eisosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in eisosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Eis1p
    NP_013744.1
    • Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      332212..334743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182527.1 → NP_013744.1  TPA: Eis1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013744.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LLS9, B5VPF9, C7GL88, D6VZK5, Q05050
      UniProtKB/TrEMBL
      N1P068
      Conserved Domains (2) summary
      COG1196
      Location:415 → 736
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12757
      Location:324 → 442
      Eisosome1; Eisosome protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05050.1

    Gene LinkOut

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