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    MET14 adenylyl-sulfate kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853869, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MET14
    Official Full Name
    adenylyl-sulfate kinase
    Primary source
    SGD:S000001484
    Locus tag
    YKL001C
    See related
    AllianceGenome:SGD:S000001484; FungiDB:YKL001C; VEuPathDB:YKL001C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables adenylylsulfate kinase activity. Involved in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) and sulfur amino acid metabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) and PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MET14 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (438777..439385, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein YmS16 Neighboring gene ESCRT-III subunit protein DID4 Neighboring gene dynamin-like GTPase VPS1 Neighboring gene polynucleotide adenylyltransferase PAP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Construction of high sulphite-producing industrial strain of Saccharomyces cerevisiae]. Qu N, et al. Wei Sheng Wu Xue Bao, 2006 Feb. PMID 16579462
    2. Cloning, nucleotide sequence, and regulation of MET14, the gene encoding the APS kinase of Saccharomyces cerevisiae. Korch C, et al. Mol Gen Genet, 1991 Sep. PMID 1654509
    3. Properties of the purified APS-kinase from Escherichia coli and Saccharomyces cerevisiae. Schriek U, et al. Arch Microbiol, 1986 Jun. PMID 3019265
    4. Isolation and subcloning analysis of functional centromere DNA (CEN11) from Saccharomyces cerevisiae chromosome XI. Fitzgerald-Hayes M, et al. Mol Cell Biol, 1982 Jan. PMID 6287222, Free PMC Article
    5. Differential transcriptional regulation of sulfur assimilation gene homologues in the Saccharomyces carlsbergensis yeast species hybrid. Johannesen PF, et al. FEMS Yeast Res, 2002 Jan. PMID 12702335

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylylsulfate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylylsulfate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylylsulfate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylylsulfate kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hydrogen sulfide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfur amino acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    adenylyl-sulfate kinase
    NP_012925.3
    • Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      438777..439385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179567.3 → NP_012925.3  TPA: adenylyl-sulfate kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012925.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXT6, Q02196
      UniProtKB/TrEMBL
      A6ZZW5, B3LR84, B5VME9, C7GQG8, C8ZCG6, G2WI32, N1NZE6
      Conserved Domains (1) summary
      TIGR00455
      Location:7 → 192
      apsK; adenylyl-sulfate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02196.1

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