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    RGR1 Rgr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850760, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RGR1
    Official Full Name
    Rgr1p
    Primary source
    SGD:S000004061
    Locus tag
    YLR071C
    See related
    AllianceGenome:SGD:S000004061; FungiDB:YLR071C; VEuPathDB:YLR071C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MED14
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and TFIIB-class transcription factor binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Part of core mediator complex. Orthologous to human MED14 (mediator complex subunit 14). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RGR1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (275378..278626, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Mef1p Neighboring gene D-xylulose reductase XYL2 Neighboring gene Lam6p Neighboring gene Rfu1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Upstream nucleosomes and Rgr1p are required for nucleosomal repression of transcription. Moss DR, et al. Mol Microbiol, 2000 Jun. PMID 10931280
    2. Structure and molecular analysis of RGR1, a gene required for glucose repression of Saccharomyces cerevisiae. Sakai A, et al. Mol Cell Biol, 1990 Aug. PMID 2196447, Free PMC Article
    3. Postrecruitment Function of Yeast Med6 Protein during the Transcriptional Activation by Mediator Complex. Kim GS, et al. Biochem Res Int, 2018. PMID 29992056, Free PMC Article
    4. Genetic and physical interactions between yeast RGR1 and SIN4 in chromatin organization and transcriptional regulation. Jiang YW, et al. Genetics, 1995 May. PMID 7635307, Free PMC Article
    5. Architectural Mediator subunits are differentially essential for global transcription in Saccharomyces cerevisiae. Tourigny JP, et al. Genetics, 2021 Mar 31. PMID 33789343, Free PMC Article

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Architectural Mediator subunits are differentially essential for global transcription in Saccharomyces cerevisiae.
      Title: Architectural Mediator subunits are differentially essential for global transcription in Saccharomyces cerevisiae.
    2. Mediator tail subunits are required for complete repression of ADH2 expression and truncation of Med14 dramatically reduces glucose repression of ADH2/lacZ expression.
      Title: Snf1-independent, glucose-resistant transcription of Adr1-dependent genes in a mediator mutant of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables TFIIB-class transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rgr1p
    NP_013172.1
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      275378..278626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181958.1 → NP_013172.1  TPA: Rgr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013172.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY72, P19263, Q07999
      UniProtKB/TrEMBL
      G2WIR3
      Conserved Domains (1) summary
      pfam08638
      Location:89 → 292
      Med14; Mediator complex subunit MED14
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19263.2

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