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    CYT2 cytochrome c1 heme lyase CYT2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853775, updated on 18-Sep-2024

    Summary

    Official Symbol
    CYT2
    Official Full Name
    cytochrome c1 heme lyase CYT2
    Primary source
    SGD:S000001570
    Locus tag
    YKL087C
    See related
    AllianceGenome:SGD:S000001570; FungiDB:YKL087C; VEuPathDB:YKL087C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables holocytochrome-c synthase activity. Involved in cytochrome c-heme linkage. Located in mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 1 and microphthalmia. Orthologous to human HCCS (holocytochrome c synthase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See CYT2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (277189..277863, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mif2p Neighboring gene phosphopantothenoylcysteine decarboxylase complex subunit CAB3 Neighboring gene sulfiredoxin Neighboring gene malate dehydrogenase MDH1

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables holocytochrome-c synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables holocytochrome-c synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables holocytochrome-c synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cytochrome c-heme linkage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytochrome c1 heme lyase CYT2
    NP_012836.1
    • Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; human homolog HCCS can complement yeast cyt2 null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      277189..277863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179653.1NP_012836.1  TPA: cytochrome c1 heme lyase CYT2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012836.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXK1, Q00873
      UniProtKB/TrEMBL
      A6ZZN1, B3LR05, B5VM71, C7GVM3, C8ZC87, G2WHU6
      Conserved Domains (1) summary
      pfam01265
      Location:57218
      Cyto_heme_lyase; Cytochrome c/c1 heme lyase