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    HOT13 Hot13p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853778, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HOT13
    Official Full Name
    Hot13p
    Primary source
    SGD:S000001567
    Locus tag
    YKL084W
    See related
    AllianceGenome:SGD:S000001567; FungiDB:YKL084W; VEuPathDB:YKL084W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables zinc ion binding activity. Involved in protein import into mitochondrial intermembrane space. Located in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See HOT13 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (280509..280859)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene sulfiredoxin Neighboring gene malate dehydrogenase MDH1 Neighboring gene ribosome biosynthesis protein RRP14 Neighboring gene translation elongation factor EF1B gamma Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40. Mesecke N, et al. EMBO Rep, 2008 Nov. PMID 18787558, Free PMC Article
    2. The role of Hot13p and redox chemistry in the mitochondrial TIM22 import pathway. Curran SP, et al. J Biol Chem, 2004 Oct 15. PMID 15294910
    3. The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts. Scutenaire J, et al. Nucleic Acids Res, 2023 Jan 25. PMID 35934316, Free PMC Article
    4. Complete DNA sequence of yeast chromosome XI. Dujon B, et al. Nature, 1994 Jun 2. PMID 8196765
    5. The cellular economy of the Saccharomyces cerevisiae zinc proteome. Wang Y, et al. Metallomics, 2018 Dec 12. PMID 30358795, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein import into mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial intermembrane space IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Hot13p
    NP_012839.1
    • Zinc-binding mitochondrial intermembrane space (IMS) protein; involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      280509..280859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179650.1 → NP_012839.1  TPA: Hot13p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012839.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXK4, P36078, Q6Q598
      UniProtKB/TrEMBL
      B3LR08, C8ZC89, G2WHU9, N1P7S4
      Conserved Domains (1) summary
      COG4357
      Location:3 → 111
      COG4357; Uncharacterized protein, contains Zn-finger domain of CHY type [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36078.1

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