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    MOB1 Mob1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854700, updated on 9-Jun-2024

    Summary

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    Gene symbol
    MOB1
    Gene description
    Mob1p
    Primary source
    FungiDB:YIL106W
    Locus tag
    YIL106W
    See related
    SGD:S000001368; AllianceGenome:SGD:S000001368; VEuPathDB:YIL106W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables kinase regulator activity. Involved in mitotic cytokinesis; protein phosphorylation; and regulation of exit from mitosis. Located in cellular bud neck and mitotic spindle pole body. Part of Sid2-Mob1 complex. Orthologous to several human genes including MOB1B (MOB kinase activator 1B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MOB1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    2
    Sequence:
    Chromosome: IX; NC_001141.2 (166415..167444)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene putative metalloendopeptidase Neighboring gene 6-phosphofructo-2-kinase Neighboring gene uncharacterized protein Neighboring gene phosphatidylinositol 4,5-bisphosphate-binding protein Neighboring gene Hsp90 cochaperone SHQ1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alfalfa Mob1-like proteins are involved in cell proliferation and are localized in the cell division plane during cytokinesis. Citterio S, et al. Exp Cell Res, 2006 Apr 15. PMID 16460730
    2. The identification of transposon-tagged mutations in essential genes that affect cell morphology in Saccharomyces cerevisiae. Chun KT, et al. Genetics, 1996 Jan. PMID 8770583, Free PMC Article
    3. Structural and functional analysis of Saccharomyces cerevisiae Mob1. Mrkobrada S, et al. J Mol Biol, 2006 Sep 22. PMID 16934835
    4. Regulation of the localization of Dbf2 and mob1 during cell division of saccharomyces cerevisiae. Yoshida S, et al. Genes Genet Syst, 2001 Apr. PMID 11434459
    5. Dual Regulation of the mitotic exit network (MEN) by PP2A-Cdc55 phosphatase. Baro B, et al. PLoS Genet, 2013. PMID 24339788, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that polo-like kinase Cdc5 first phosphorylates Hof1 to allow subsequent phosphorylation by Dbf2-Mob1.
      Title: Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis.
    2. Cdk1 phosphorylates the Mob1 protein to inhibit the activity of Dbf2-Mob1 kinase that regulates Cdc14 phosphatase.
      Title: Mutual regulation of cyclin-dependent kinase and the mitotic exit network.
    3. Study shows that a MEN component, protein kinase Dbf2-Mob1, promotes transfer of Cdc14 to the cytoplasm and consequent exit from mitosis by direct phosphorylation of Cdc14 on serine and threonine residues adjacent to a nuclear localization signal.
      Title: Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis.
    4. required for establishing passenger protein localization on the mitotic spindle
      Title: The mitotic exit network Mob1p-Dbf2p kinase complex localizes to the nucleus and regulates passenger protein localization.
    5. 2.0 A X-ray crystal structure
      Title: Structural and functional analysis of Saccharomyces cerevisiae Mob1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of exit from mitosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Sid2-Mob1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Sid2-Mob1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear periphery HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mob1p
    NP_012160.2
    • Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      166415..167444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179454.1 → NP_012160.2  TPA: Mob1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012160.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVI1, P40484
      UniProtKB/TrEMBL
      A6ZVH1, B3LTV3, C8ZAD9, G2WG46, N1P0W7
      Conserved Domains (1) summary
      pfam03637
      Location:134 → 304
      Mob1_phocein; Mob1/phocein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40484.2

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