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    FMC1 Fmc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854709, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FMC1
    Official Full Name
    Fmc1p
    Primary source
    SGD:S000001360
    Locus tag
    YIL098C
    See related
    AllianceGenome:SGD:S000001360; FungiDB:YIL098C; VEuPathDB:YIL098C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in macroautophagy and mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FMC1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (179772..180239, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Xbp1p Neighboring gene glucan 1,4-alpha-glucosidase Neighboring gene glucose-induced degradation complex subunit FYV10 Neighboring gene 25S rRNA (uracil2634-N3)-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Newly imported proteins in mitochondria are particularly sensitive to aggregation. Vazquez-Calvo C, et al. Acta Physiol (Oxf), 2023 Jul. PMID 37171464, Free PMC Article
    2. A yeast-based assay identifies drugs active against human mitochondrial disorders. Couplan E, et al. Proc Natl Acad Sci U S A, 2011 Jul 19. PMID 21715656, Free PMC Article
    3. Identification of a nuclear gene (FMC1) required for the assembly/stability of yeast mitochondrial F(1)-ATPase in heat stress conditions. Lefebvre-Legendre L, et al. J Biol Chem, 2001 Mar 2. PMID 11096112
    4. Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast. Priault M, et al. Cell Death Differ, 2005 Dec. PMID 15947785
    5. Increasing mitochondrial substrate-level phosphorylation can rescue respiratory growth of an ATP synthase-deficient yeast. Schwimmer C, et al. J Biol Chem, 2005 Sep 2. PMID 15975925

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the suppression of the respiratory-growth-deficient fmc1 by the overexpressed Odc1p was not due to a restored stable ATP synthase.
      Title: Increasing mitochondrial substrate-level phosphorylation can rescue respiratory growth of an ATP synthase-deficient yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fmc1p
    NP_012168.3
    • Mitochondrial matrix protein; required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      179772..180239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179446.3 → NP_012168.3  TPA: Fmc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012168.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVI9, P40491
      UniProtKB/TrEMBL
      A6ZVH9, B3LTU5, C7GKM5, C8ZAF2, G2WG54, N1P2H5
      Conserved Domains (1) summary
      pfam13233
      Location:108 → 152
      Complex1_LYR_2; Complex1_LYR-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40491.1

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